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Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery

BACKGROUND: Cholesterol plays an important role in the action of opioid analgesics, but its association with postoperative pain has not been clarified. Our study examined the association of pre- and postoperative total serum cholesterol (TSC), and change between the pre- and postoperative TSC levels...

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Autores principales: Oh, Tak Kyu, Kim, Kwanmien, Jheon, Sanghoon, Lee, Hei-jin, Do, Sang-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Anesthesiologists 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458511/
https://www.ncbi.nlm.nih.gov/pubmed/29969888
http://dx.doi.org/10.4097/kja.d.18.00122
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author Oh, Tak Kyu
Kim, Kwanmien
Jheon, Sanghoon
Lee, Hei-jin
Do, Sang-Hwan
author_facet Oh, Tak Kyu
Kim, Kwanmien
Jheon, Sanghoon
Lee, Hei-jin
Do, Sang-Hwan
author_sort Oh, Tak Kyu
collection PubMed
description BACKGROUND: Cholesterol plays an important role in the action of opioid analgesics, but its association with postoperative pain has not been clarified. Our study examined the association of pre- and postoperative total serum cholesterol (TSC), and change between the pre- and postoperative TSC levels with postoperative pain outcomes in patients with non-small cell lung cancer (NSCLC) who underwent video-assisted thoracoscopic surgery (VATS) lobectomy. METHODS: We retrospectively reviewed medical records of patients with NSCLC who underwent VATS lobectomy at the Seoul National University Bundang Hospital in South Korea. We sought to determine the association between preoperative TSC, TSC on postoperative day (POD) 0–1, and pre- and postoperative changes in TSC by comparing numeric rating scale (NRS) scores on POD 0, 1, and 2 and total morphine equivalent consumption on POD 0–2. Multivariate linear regression analyses were used, and P < 0.05 was considered statistically significant. RESULTS: A total of 1,720 patients with NSCLC who underwent VATS lobectomy were included in the analysis. The change in TSC, preoperative TSC, and postoperative TSC showed no associations with morphine equivalent consumption on POD 0–2 (P > 0.05). In addition, the changes in TSC, preoperative TSC, and postoperative TSC were not associated with postoperative NRS pain score on POD 0, 1, and 2 (P > 0.05). CONCLUSIONS: Our results indicated that no significant association was observed between pre- and postoperative TSC level and postoperative pain outcome after VATS lobectomy of the lung.
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spelling pubmed-64585112019-04-19 Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery Oh, Tak Kyu Kim, Kwanmien Jheon, Sanghoon Lee, Hei-jin Do, Sang-Hwan Korean J Anesthesiol Clinical Research Article BACKGROUND: Cholesterol plays an important role in the action of opioid analgesics, but its association with postoperative pain has not been clarified. Our study examined the association of pre- and postoperative total serum cholesterol (TSC), and change between the pre- and postoperative TSC levels with postoperative pain outcomes in patients with non-small cell lung cancer (NSCLC) who underwent video-assisted thoracoscopic surgery (VATS) lobectomy. METHODS: We retrospectively reviewed medical records of patients with NSCLC who underwent VATS lobectomy at the Seoul National University Bundang Hospital in South Korea. We sought to determine the association between preoperative TSC, TSC on postoperative day (POD) 0–1, and pre- and postoperative changes in TSC by comparing numeric rating scale (NRS) scores on POD 0, 1, and 2 and total morphine equivalent consumption on POD 0–2. Multivariate linear regression analyses were used, and P < 0.05 was considered statistically significant. RESULTS: A total of 1,720 patients with NSCLC who underwent VATS lobectomy were included in the analysis. The change in TSC, preoperative TSC, and postoperative TSC showed no associations with morphine equivalent consumption on POD 0–2 (P > 0.05). In addition, the changes in TSC, preoperative TSC, and postoperative TSC were not associated with postoperative NRS pain score on POD 0, 1, and 2 (P > 0.05). CONCLUSIONS: Our results indicated that no significant association was observed between pre- and postoperative TSC level and postoperative pain outcome after VATS lobectomy of the lung. Korean Society of Anesthesiologists 2019-04 2018-07-04 /pmc/articles/PMC6458511/ /pubmed/29969888 http://dx.doi.org/10.4097/kja.d.18.00122 Text en Copyright © The Korean Society of Anesthesiologists, 2019 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research Article
Oh, Tak Kyu
Kim, Kwanmien
Jheon, Sanghoon
Lee, Hei-jin
Do, Sang-Hwan
Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
title Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
title_full Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
title_fullStr Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
title_full_unstemmed Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
title_short Association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
title_sort association between perioperative cholesterol level and analgesia after video-assisted thoracoscopic surgery
topic Clinical Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458511/
https://www.ncbi.nlm.nih.gov/pubmed/29969888
http://dx.doi.org/10.4097/kja.d.18.00122
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