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Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain

BACKGROUND: Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces a prolonged anti-nociceptive state. To explore underlying mechanisms, broad t...

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Detalles Bibliográficos
Autores principales:	Jacobson, Gregory M., Voss, Logan J., Klockars, Anica, Bird, Steve, Dimitrov, Ivo, Denny, William A., Olszewski, Pawel K., Sleigh, James W., Harvey, Martyn G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458767/ https://www.ncbi.nlm.nih.gov/pubmed/30971208 http://dx.doi.org/10.1186/s12864-019-5649-6

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