Cargando…
Functional role of SGK3 in PI3K/Pten driven liver tumor development
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of PI3K catalytic subunit alpha (PIK3CA) and/or loss of Pten often occur in human...
Autores principales: | Cao, Hui, Xu, Zhong, Wang, Jingxiao, Cigliano, Antonio, Pilo, Maria G., Ribback, Silvia, Zhang, Shu, Qiao, Yu, Che, Li, Pascale, Rosa M., Calvisi, Diego F., Chen, Xin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458829/ https://www.ncbi.nlm.nih.gov/pubmed/30975125 http://dx.doi.org/10.1186/s12885-019-5551-2 |
Ejemplares similares
-
PI3K/AKT/mTOR pathway plays a major pathogenetic role in glycogen accumulation and tumor development in renal distal tubules of rats and men
por: Ribback, Silvia, et al.
Publicado: (2015) -
Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
por: Xu, Zhong, et al.
Publicado: (2018) -
Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis
por: Jia, Jiaoyuan, et al.
Publicado: (2020) -
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis
por: Mancarella, Serena, et al.
Publicado: (2020) -
Inhibition of HSF1 suppresses the growth of hepatocarcinoma cell lines in vitro and AKT-driven hepatocarcinogenesis in mice
por: Cigliano, Antonio, et al.
Publicado: (2017)