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The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup

The aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase prot...

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Autores principales: Pucher, Beata, Sobieska, Magdalena, Grzegorowski, Michal, Szydlowski, Jaroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458876/
https://www.ncbi.nlm.nih.gov/pubmed/31049027
http://dx.doi.org/10.1155/2019/6518308
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author Pucher, Beata
Sobieska, Magdalena
Grzegorowski, Michal
Szydlowski, Jaroslaw
author_facet Pucher, Beata
Sobieska, Magdalena
Grzegorowski, Michal
Szydlowski, Jaroslaw
author_sort Pucher, Beata
collection PubMed
description The aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase proteins (APP), such as C-reactive protein (CRP), alpha-1-antitrypsin (AT), alpha-1-antichymotrypsin (ACT), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), transferrin (Tf), alpha-2-macroglobulin (A2M), and haptoglobin (Hp) were obtained at 3 time points. The glycosylation profiles of AGP, ACT, and Tf were completed. An increased AGP level was observed in girls. The AGP glycosylation revealed the advantage of the W0 variant over the W1 variant. W1 and W2 were decreased in boys. W3 emerged in boys. The Tf concentration and T4 variant were lower compared to the control group. The A2M level was lower after treatment. The Hp and AT levels were decreased a few weeks later. The ACT glycosylation revealed a decrease of the A4 variant in boys. In conclusion, the inflammatory reaction during pseudocroup was of low intensity. The APP glycosylation suggested a chronic process. In a follow-up investigation, no normalization of the parameters was noted, but signs of persistent inflammation were observed.
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spelling pubmed-64588762019-05-02 The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup Pucher, Beata Sobieska, Magdalena Grzegorowski, Michal Szydlowski, Jaroslaw Mediators Inflamm Research Article The aim of the study was to evaluate the inflammatory reaction in children with pseudocroup and compare it with other laryngological diseases according to the available literature data. The study group included 51 children hospitalized because of pseudocroup. The measurements of the acute phase proteins (APP), such as C-reactive protein (CRP), alpha-1-antitrypsin (AT), alpha-1-antichymotrypsin (ACT), alpha-1-acid glycoprotein (AGP), ceruloplasmin (Cp), transferrin (Tf), alpha-2-macroglobulin (A2M), and haptoglobin (Hp) were obtained at 3 time points. The glycosylation profiles of AGP, ACT, and Tf were completed. An increased AGP level was observed in girls. The AGP glycosylation revealed the advantage of the W0 variant over the W1 variant. W1 and W2 were decreased in boys. W3 emerged in boys. The Tf concentration and T4 variant were lower compared to the control group. The A2M level was lower after treatment. The Hp and AT levels were decreased a few weeks later. The ACT glycosylation revealed a decrease of the A4 variant in boys. In conclusion, the inflammatory reaction during pseudocroup was of low intensity. The APP glycosylation suggested a chronic process. In a follow-up investigation, no normalization of the parameters was noted, but signs of persistent inflammation were observed. Hindawi 2019-03-26 /pmc/articles/PMC6458876/ /pubmed/31049027 http://dx.doi.org/10.1155/2019/6518308 Text en Copyright © 2019 Beata Pucher et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Pucher, Beata
Sobieska, Magdalena
Grzegorowski, Michal
Szydlowski, Jaroslaw
The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
title The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
title_full The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
title_fullStr The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
title_full_unstemmed The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
title_short The Acute Phase Proteins Reaction in Children Suffering from Pseudocroup
title_sort acute phase proteins reaction in children suffering from pseudocroup
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458876/
https://www.ncbi.nlm.nih.gov/pubmed/31049027
http://dx.doi.org/10.1155/2019/6518308
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