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Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement

OBJECTIVE: Facial synkinesis is a severe sequelae of facial nerve malfunction. Once the synkinesis is established, it is extremely difficult for patients to recover. Given that the restoration of motor or sensory function after peripheral nerve injury was closely related with cortical plasticity, we...

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Autores principales: Wu, Jia-jia, Lu, Ye-chen, Zheng, Mou-xiong, Hua, Xu-yun, Xu, Jian-guang, Ding, Wei, Shan, Chun-lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458910/
https://www.ncbi.nlm.nih.gov/pubmed/31049055
http://dx.doi.org/10.1155/2019/7235808
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author Wu, Jia-jia
Lu, Ye-chen
Zheng, Mou-xiong
Hua, Xu-yun
Xu, Jian-guang
Ding, Wei
Shan, Chun-lei
author_facet Wu, Jia-jia
Lu, Ye-chen
Zheng, Mou-xiong
Hua, Xu-yun
Xu, Jian-guang
Ding, Wei
Shan, Chun-lei
author_sort Wu, Jia-jia
collection PubMed
description OBJECTIVE: Facial synkinesis is a severe sequelae of facial nerve malfunction. Once the synkinesis is established, it is extremely difficult for patients to recover. Given that the restoration of motor or sensory function after peripheral nerve injury was closely related with cortical plasticity, we investigated cortical plasticity in facial synkinesis patients by the frequency-specific data which remains largely uncharacterized. MATERIALS AND METHODS: Resting-state fMRI was conducted in 20 facial synkinesis patients and 19 healthy controls, and the amplitude of low-frequency fluctuation (ALFF) in five different frequency bands (slow-6: 0-0.01 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.167 Hz; and slow-2: 0.167-0.25 Hz) was calculated, respectively. And the relationship between ALFF and clinical outcomes was also analyzed. RESULTS: Comparing with the healthy controls, facial synkinesis patients showed significantly different ALFF values, mainly in the sensorimotor areas. Furthermore, increased ALFF of the ipsilateral insula in the slow-6 band was significantly related with better facial nerve function. CONCLUSION: Increased ALFF values in the ipsilateral insula might reflect an abnormal state of hypercompensation in motor control of facial synkinesis patients. It provided valuable spatial information about the functionally aberrant regions, which implied the possible involvement of motor control system in facial synkinesis.
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spelling pubmed-64589102019-05-02 Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement Wu, Jia-jia Lu, Ye-chen Zheng, Mou-xiong Hua, Xu-yun Xu, Jian-guang Ding, Wei Shan, Chun-lei Neural Plast Research Article OBJECTIVE: Facial synkinesis is a severe sequelae of facial nerve malfunction. Once the synkinesis is established, it is extremely difficult for patients to recover. Given that the restoration of motor or sensory function after peripheral nerve injury was closely related with cortical plasticity, we investigated cortical plasticity in facial synkinesis patients by the frequency-specific data which remains largely uncharacterized. MATERIALS AND METHODS: Resting-state fMRI was conducted in 20 facial synkinesis patients and 19 healthy controls, and the amplitude of low-frequency fluctuation (ALFF) in five different frequency bands (slow-6: 0-0.01 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.167 Hz; and slow-2: 0.167-0.25 Hz) was calculated, respectively. And the relationship between ALFF and clinical outcomes was also analyzed. RESULTS: Comparing with the healthy controls, facial synkinesis patients showed significantly different ALFF values, mainly in the sensorimotor areas. Furthermore, increased ALFF of the ipsilateral insula in the slow-6 band was significantly related with better facial nerve function. CONCLUSION: Increased ALFF values in the ipsilateral insula might reflect an abnormal state of hypercompensation in motor control of facial synkinesis patients. It provided valuable spatial information about the functionally aberrant regions, which implied the possible involvement of motor control system in facial synkinesis. Hindawi 2019-03-27 /pmc/articles/PMC6458910/ /pubmed/31049055 http://dx.doi.org/10.1155/2019/7235808 Text en Copyright © 2019 Jia-jia Wu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Jia-jia
Lu, Ye-chen
Zheng, Mou-xiong
Hua, Xu-yun
Xu, Jian-guang
Ding, Wei
Shan, Chun-lei
Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
title Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
title_full Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
title_fullStr Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
title_full_unstemmed Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
title_short Motor Control Deficits in Facial Synkinesis Patients: Neuroimaging Evidences of Cerebral Cortex Involvement
title_sort motor control deficits in facial synkinesis patients: neuroimaging evidences of cerebral cortex involvement
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458910/
https://www.ncbi.nlm.nih.gov/pubmed/31049055
http://dx.doi.org/10.1155/2019/7235808
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