Cargando…

Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer

OBJECTIVES: Sarcopenia is known as a geriatric syndrome associated with increased disability and decreased survival in elderly patients. In oncological patients, pretreatment low skeletal muscle mass (SMM), sometimes referred to as sarcopenia, is an emerging negative prognostic factor. Commonly, onl...

Descripción completa

Detalles Bibliográficos
Autores principales: Chargi, N., Bril, S. I., Emmelot-Vonk, M. H., de Bree, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458984/
https://www.ncbi.nlm.nih.gov/pubmed/30830300
http://dx.doi.org/10.1007/s00405-019-05361-4
_version_ 1783410126090141696
author Chargi, N.
Bril, S. I.
Emmelot-Vonk, M. H.
de Bree, R.
author_facet Chargi, N.
Bril, S. I.
Emmelot-Vonk, M. H.
de Bree, R.
author_sort Chargi, N.
collection PubMed
description OBJECTIVES: Sarcopenia is known as a geriatric syndrome associated with increased disability and decreased survival in elderly patients. In oncological patients, pretreatment low skeletal muscle mass (SMM), sometimes referred to as sarcopenia, is an emerging negative prognostic factor. Commonly, only SMM is assessed in cancer patients. Sarcopenia is defined as the combination of low SMM and low muscle function (MF). We investigated the relation between SMM, MF, sarcopenia (SMM and MF combined), and overall survival (OS) in a group of elderly patients with head-and-neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: A retrospective study in elderly HNSCC patients treated between 2015 and 2018 was performed. The prognostic value of SMM and MF seperately, and sarcopenia was investigated. RESULTS: Eighty-five patients were included of whom 48.2% had sarcopenia. The median OS was significantly worse for patients treated with curative intent with sarcopenia (12.07 months; IQR 3.64–21.82) compared to patients without sarcopenia (13.60 months; IQR 5.98-27.00) (HR 2.80; 95% CI 1.14–6.88; p = 0.03). SMM and MF seperately were not significant predictors of OS. CONCLUSION: Sarcopenia is associated with impaired OS in elderly HNSCC patients. Sarcopenia, defined as the combination of low SMM and low MF, appears to be a better predictor of OS than low SMM or low MF separately.
format Online
Article
Text
id pubmed-6458984
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-64589842019-05-03 Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer Chargi, N. Bril, S. I. Emmelot-Vonk, M. H. de Bree, R. Eur Arch Otorhinolaryngol Head & Neck OBJECTIVES: Sarcopenia is known as a geriatric syndrome associated with increased disability and decreased survival in elderly patients. In oncological patients, pretreatment low skeletal muscle mass (SMM), sometimes referred to as sarcopenia, is an emerging negative prognostic factor. Commonly, only SMM is assessed in cancer patients. Sarcopenia is defined as the combination of low SMM and low muscle function (MF). We investigated the relation between SMM, MF, sarcopenia (SMM and MF combined), and overall survival (OS) in a group of elderly patients with head-and-neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: A retrospective study in elderly HNSCC patients treated between 2015 and 2018 was performed. The prognostic value of SMM and MF seperately, and sarcopenia was investigated. RESULTS: Eighty-five patients were included of whom 48.2% had sarcopenia. The median OS was significantly worse for patients treated with curative intent with sarcopenia (12.07 months; IQR 3.64–21.82) compared to patients without sarcopenia (13.60 months; IQR 5.98-27.00) (HR 2.80; 95% CI 1.14–6.88; p = 0.03). SMM and MF seperately were not significant predictors of OS. CONCLUSION: Sarcopenia is associated with impaired OS in elderly HNSCC patients. Sarcopenia, defined as the combination of low SMM and low MF, appears to be a better predictor of OS than low SMM or low MF separately. Springer Berlin Heidelberg 2019-03-04 2019 /pmc/articles/PMC6458984/ /pubmed/30830300 http://dx.doi.org/10.1007/s00405-019-05361-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Head & Neck
Chargi, N.
Bril, S. I.
Emmelot-Vonk, M. H.
de Bree, R.
Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
title Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
title_full Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
title_fullStr Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
title_full_unstemmed Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
title_short Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
title_sort sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer
topic Head & Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458984/
https://www.ncbi.nlm.nih.gov/pubmed/30830300
http://dx.doi.org/10.1007/s00405-019-05361-4
work_keys_str_mv AT chargin sarcopeniaisaprognosticfactorforoverallsurvivalinelderlypatientswithheadandneckcancer
AT brilsi sarcopeniaisaprognosticfactorforoverallsurvivalinelderlypatientswithheadandneckcancer
AT emmelotvonkmh sarcopeniaisaprognosticfactorforoverallsurvivalinelderlypatientswithheadandneckcancer
AT debreer sarcopeniaisaprognosticfactorforoverallsurvivalinelderlypatientswithheadandneckcancer