Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination

The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A key player in this process is the cleavage and polyadenylation (CPA) factor PCF11, which directly binds to the Pol II C-terminal domain and dismantles elongating Pol II from DNA in vitro. We demonstrat...

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Detalles Bibliográficos
Autores principales: Kamieniarz-Gdula, Kinga, Gdula, Michal R., Panser, Karin, Nojima, Takayuki, Monks, Joan, Wiśniewski, Jacek R., Riepsaame, Joey, Brockdorff, Neil, Pauli, Andrea, Proudfoot, Nick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458999/
https://www.ncbi.nlm.nih.gov/pubmed/30819644
http://dx.doi.org/10.1016/j.molcel.2019.01.027

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