RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

Ral GTPases are RAS effector molecules and by implication a potential therapeutic target for RAS mutant cancer. However, very little is known about their roles in stem cells and tissue homeostasis. Using Drosophila, we identified expression of RalA in intestinal stem cells (ISCs) and progenitor cell...

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Detalles Bibliográficos
Autores principales: Johansson, Joel, Naszai, Mate, Hodder, Michael C., Pickering, Karen A., Miller, Bryan W., Ridgway, Rachel A., Yu, Yachuan, Peschard, Pascal, Brachmann, Saskia, Campbell, Andrew D., Cordero, Julia B., Sansom, Owen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459002/
https://www.ncbi.nlm.nih.gov/pubmed/30853556
http://dx.doi.org/10.1016/j.stem.2019.02.002

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