The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer

The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and pentraxins. These molecules are involved in innate immune responses by recognizing microbial moieties and damaged tissues, activating comple...

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Autores principales: Doni, Andrea, Stravalaci, Matteo, Inforzato, Antonio, Magrini, Elena, Mantovani, Alberto, Garlanda, Cecilia, Bottazzi, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459138/
https://www.ncbi.nlm.nih.gov/pubmed/31019517
http://dx.doi.org/10.3389/fimmu.2019.00712
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author Doni, Andrea
Stravalaci, Matteo
Inforzato, Antonio
Magrini, Elena
Mantovani, Alberto
Garlanda, Cecilia
Bottazzi, Barbara
author_facet Doni, Andrea
Stravalaci, Matteo
Inforzato, Antonio
Magrini, Elena
Mantovani, Alberto
Garlanda, Cecilia
Bottazzi, Barbara
author_sort Doni, Andrea
collection PubMed
description The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and pentraxins. These molecules are involved in innate immune responses by recognizing microbial moieties and damaged tissues, activating complement, exerting opsonic activity and facilitating phagocytosis, and regulating inflammation. The long pentraxin PTX3 is a prototypic humoral pattern recognition molecule that, in addition to providing defense against infectious agents, plays several functions in tissue repair and regulation of cancer-related inflammation. Characterization of the PTX3 molecular structure and biochemical properties, and insights into its interactome and multiple roles in tissue damage and remodeling support the view that microbial and matrix recognition are evolutionarily conserved functions of humoral innate immunity molecules.
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spelling pubmed-64591382019-04-24 The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer Doni, Andrea Stravalaci, Matteo Inforzato, Antonio Magrini, Elena Mantovani, Alberto Garlanda, Cecilia Bottazzi, Barbara Front Immunol Immunology The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and pentraxins. These molecules are involved in innate immune responses by recognizing microbial moieties and damaged tissues, activating complement, exerting opsonic activity and facilitating phagocytosis, and regulating inflammation. The long pentraxin PTX3 is a prototypic humoral pattern recognition molecule that, in addition to providing defense against infectious agents, plays several functions in tissue repair and regulation of cancer-related inflammation. Characterization of the PTX3 molecular structure and biochemical properties, and insights into its interactome and multiple roles in tissue damage and remodeling support the view that microbial and matrix recognition are evolutionarily conserved functions of humoral innate immunity molecules. Frontiers Media S.A. 2019-04-04 /pmc/articles/PMC6459138/ /pubmed/31019517 http://dx.doi.org/10.3389/fimmu.2019.00712 Text en Copyright © 2019 Doni, Stravalaci, Inforzato, Magrini, Mantovani, Garlanda and Bottazzi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Doni, Andrea
Stravalaci, Matteo
Inforzato, Antonio
Magrini, Elena
Mantovani, Alberto
Garlanda, Cecilia
Bottazzi, Barbara
The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
title The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
title_full The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
title_fullStr The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
title_full_unstemmed The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
title_short The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer
title_sort long pentraxin ptx3 as a link between innate immunity, tissue remodeling, and cancer
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459138/
https://www.ncbi.nlm.nih.gov/pubmed/31019517
http://dx.doi.org/10.3389/fimmu.2019.00712
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