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Exploring distinct default mode and semantic networks using a systematic ICA approach

Resting-state networks (RSNs; groups of regions consistently co-activated without an explicit task) are hugely influential in modern brain research. Despite this popularity, the link between specific RSNs and their functions remains elusive, limiting the impact on cognitive neuroscience (where the g...

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Autores principales: Jackson, Rebecca L., Cloutman, Lauren L., Lambon Ralph, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Masson 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459395/
https://www.ncbi.nlm.nih.gov/pubmed/30716610
http://dx.doi.org/10.1016/j.cortex.2018.12.019
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author Jackson, Rebecca L.
Cloutman, Lauren L.
Lambon Ralph, Matthew A.
author_facet Jackson, Rebecca L.
Cloutman, Lauren L.
Lambon Ralph, Matthew A.
author_sort Jackson, Rebecca L.
collection PubMed
description Resting-state networks (RSNs; groups of regions consistently co-activated without an explicit task) are hugely influential in modern brain research. Despite this popularity, the link between specific RSNs and their functions remains elusive, limiting the impact on cognitive neuroscience (where the goal is to link cognition to neural systems). Here we present a series of logical steps to formally test the relationship between a coherent RSN with a cognitive domain. This approach is applied to a challenging and significant test-case; extracting a recently-proposed semantic RSN, determining its relation with a well-known RSN, the default mode network (DMN), and assessing their roles in semantic cognition. Results showed the DMN and semantic network are two distinct coherent RSNs. Assessing the cognitive signature of these spatiotemporally coherent networks directly (and therefore accounting for overlapping networks) showed involvement of the proposed semantic network, but not the DMN, in task-based semantic cognition. Following the steps presented here, researchers could formally test specific hypotheses regarding the function of RSNs, including other possible functions of the DMN.
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spelling pubmed-64593952019-04-22 Exploring distinct default mode and semantic networks using a systematic ICA approach Jackson, Rebecca L. Cloutman, Lauren L. Lambon Ralph, Matthew A. Cortex Article Resting-state networks (RSNs; groups of regions consistently co-activated without an explicit task) are hugely influential in modern brain research. Despite this popularity, the link between specific RSNs and their functions remains elusive, limiting the impact on cognitive neuroscience (where the goal is to link cognition to neural systems). Here we present a series of logical steps to formally test the relationship between a coherent RSN with a cognitive domain. This approach is applied to a challenging and significant test-case; extracting a recently-proposed semantic RSN, determining its relation with a well-known RSN, the default mode network (DMN), and assessing their roles in semantic cognition. Results showed the DMN and semantic network are two distinct coherent RSNs. Assessing the cognitive signature of these spatiotemporally coherent networks directly (and therefore accounting for overlapping networks) showed involvement of the proposed semantic network, but not the DMN, in task-based semantic cognition. Following the steps presented here, researchers could formally test specific hypotheses regarding the function of RSNs, including other possible functions of the DMN. Masson 2019-04 /pmc/articles/PMC6459395/ /pubmed/30716610 http://dx.doi.org/10.1016/j.cortex.2018.12.019 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jackson, Rebecca L.
Cloutman, Lauren L.
Lambon Ralph, Matthew A.
Exploring distinct default mode and semantic networks using a systematic ICA approach
title Exploring distinct default mode and semantic networks using a systematic ICA approach
title_full Exploring distinct default mode and semantic networks using a systematic ICA approach
title_fullStr Exploring distinct default mode and semantic networks using a systematic ICA approach
title_full_unstemmed Exploring distinct default mode and semantic networks using a systematic ICA approach
title_short Exploring distinct default mode and semantic networks using a systematic ICA approach
title_sort exploring distinct default mode and semantic networks using a systematic ica approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459395/
https://www.ncbi.nlm.nih.gov/pubmed/30716610
http://dx.doi.org/10.1016/j.cortex.2018.12.019
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