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Efficacy, Safety, and Performance of Isolated Left vs. Right Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled Trial
BACKGROUND: Considering the potential deleterious effects of right ventricular (RV) pacing, the hypothesis of this study is that isolated left ventricular (LV) pacing through the coronary sinus is safe and may provide better clinical and echocardiographic benefits to patients with bradyarrhythmias a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Cardiologia - SBC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459436/ https://www.ncbi.nlm.nih.gov/pubmed/30994720 http://dx.doi.org/10.5935/abc.20180275 |
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author | Crevelari, Elizabeth Sartori da Silva, Katia Regina Albertini, Caio Marcos de Moraes Vieira, Marcelo Luiz Campos Martinelli Filho, Martino Costa, Roberto |
author_facet | Crevelari, Elizabeth Sartori da Silva, Katia Regina Albertini, Caio Marcos de Moraes Vieira, Marcelo Luiz Campos Martinelli Filho, Martino Costa, Roberto |
author_sort | Crevelari, Elizabeth Sartori |
collection | PubMed |
description | BACKGROUND: Considering the potential deleterious effects of right ventricular (RV) pacing, the hypothesis of this study is that isolated left ventricular (LV) pacing through the coronary sinus is safe and may provide better clinical and echocardiographic benefits to patients with bradyarrhythmias and normal ventricular function requiring heart rate correction alone. OBJECTIVE: To assess the safety, efficacy, and effects of LV pacing using an active-fixation coronary sinus lead in comparison with RV pacing, in patients eligible for conventional pacemaker (PM) implantation. METHODS: Randomized, controlled, and single-blinded clinical trial in adult patients submitted to PM implantation due to bradyarrhythmias and systolic ventricular function ≥ 0.40. Randomization (RV vs. LV) occurred before PM implantation. The main results of the study were procedural success, safety, and efficacy. Secondary results were clinical and echocardiographic changes. Chi-squared test, Fisher's exact test and Student's t-test were used, considering a significance level of 5%. RESULTS: From June 2012 to January 2014, 91 patients were included, 36 in the RV Group and 55 in the LV Group. Baseline characteristics of patients in both groups were similar. PM implantation was performed successfully and without any complications in all patients in the RV group. Of the 55 patients initially allocated into the LV group, active-fixation coronary sinus lead implantation was not possible in 20 (36.4%) patients. The most frequent complication was phrenic nerve stimulation, detected in 9 (25.7%) patients in the LV group. During the follow-up period, there were no hospitalizations due to heart failure. Reductions of more than 10% in left ventricular ejection fraction were observed in 23.5% of patients in the RV group and 20.6% of those in the LV group (p = 0.767). Tissue Doppler analysis showed that 91.2% of subjects in the RV group and 68.8% of those in the LV group had interventricular dyssynchrony (p = 0.022). CONCLUSION: The procedural success rate of LV implant was low, and the safety of the procedure was influenced mainly by the high rate of phrenic nerve stimulation in the postoperative period. |
format | Online Article Text |
id | pubmed-6459436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-64594362019-04-17 Efficacy, Safety, and Performance of Isolated Left vs. Right Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled Trial Crevelari, Elizabeth Sartori da Silva, Katia Regina Albertini, Caio Marcos de Moraes Vieira, Marcelo Luiz Campos Martinelli Filho, Martino Costa, Roberto Arq Bras Cardiol Original Article BACKGROUND: Considering the potential deleterious effects of right ventricular (RV) pacing, the hypothesis of this study is that isolated left ventricular (LV) pacing through the coronary sinus is safe and may provide better clinical and echocardiographic benefits to patients with bradyarrhythmias and normal ventricular function requiring heart rate correction alone. OBJECTIVE: To assess the safety, efficacy, and effects of LV pacing using an active-fixation coronary sinus lead in comparison with RV pacing, in patients eligible for conventional pacemaker (PM) implantation. METHODS: Randomized, controlled, and single-blinded clinical trial in adult patients submitted to PM implantation due to bradyarrhythmias and systolic ventricular function ≥ 0.40. Randomization (RV vs. LV) occurred before PM implantation. The main results of the study were procedural success, safety, and efficacy. Secondary results were clinical and echocardiographic changes. Chi-squared test, Fisher's exact test and Student's t-test were used, considering a significance level of 5%. RESULTS: From June 2012 to January 2014, 91 patients were included, 36 in the RV Group and 55 in the LV Group. Baseline characteristics of patients in both groups were similar. PM implantation was performed successfully and without any complications in all patients in the RV group. Of the 55 patients initially allocated into the LV group, active-fixation coronary sinus lead implantation was not possible in 20 (36.4%) patients. The most frequent complication was phrenic nerve stimulation, detected in 9 (25.7%) patients in the LV group. During the follow-up period, there were no hospitalizations due to heart failure. Reductions of more than 10% in left ventricular ejection fraction were observed in 23.5% of patients in the RV group and 20.6% of those in the LV group (p = 0.767). Tissue Doppler analysis showed that 91.2% of subjects in the RV group and 68.8% of those in the LV group had interventricular dyssynchrony (p = 0.022). CONCLUSION: The procedural success rate of LV implant was low, and the safety of the procedure was influenced mainly by the high rate of phrenic nerve stimulation in the postoperative period. Sociedade Brasileira de Cardiologia - SBC 2019-04 /pmc/articles/PMC6459436/ /pubmed/30994720 http://dx.doi.org/10.5935/abc.20180275 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Original Article Crevelari, Elizabeth Sartori da Silva, Katia Regina Albertini, Caio Marcos de Moraes Vieira, Marcelo Luiz Campos Martinelli Filho, Martino Costa, Roberto Efficacy, Safety, and Performance of Isolated Left vs. Right Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled Trial |
title | Efficacy, Safety, and Performance of Isolated Left vs. Right
Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled
Trial |
title_full | Efficacy, Safety, and Performance of Isolated Left vs. Right
Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled
Trial |
title_fullStr | Efficacy, Safety, and Performance of Isolated Left vs. Right
Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled
Trial |
title_full_unstemmed | Efficacy, Safety, and Performance of Isolated Left vs. Right
Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled
Trial |
title_short | Efficacy, Safety, and Performance of Isolated Left vs. Right
Ventricular Pacing in Patients with Bradyarrhythmias: A Randomized Controlled
Trial |
title_sort | efficacy, safety, and performance of isolated left vs. right
ventricular pacing in patients with bradyarrhythmias: a randomized controlled
trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459436/ https://www.ncbi.nlm.nih.gov/pubmed/30994720 http://dx.doi.org/10.5935/abc.20180275 |
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