Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

While genomic sequencing routinely identifies oncogenic alterations for the majority of cancers, many tumors harbor no discernable driver lesion. Here, we describe the exceptional molecular phenotype of a genomically quiet kidney tumor, clear cell papillary renal cell carcinoma (CCPAP). In spite of...

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Detalles Bibliográficos
Autores principales: Xu, Jianing, Reznik, Ed, Lee, Ho-Joon, Gundem, Gunes, Jonsson, Philip, Sarungbam, Judy, Bialik, Anna, Sanchez-Vega, Francisco, Creighton, Chad J, Hoekstra, Jake, Zhang, Li, Sajjakulnukit, Peter, Kremer, Daniel, Tolstyka, Zachary, Casuscelli, Jozefina, Stirdivant, Steve, Tang, Jie, Schultz, Nikolaus, Jeng, Paul, Dong, Yiyu, Su, Wenjing, Cheng, Emily H, Russo, Paul, Coleman, Jonathan A, Papaemmanuil, Elli, Chen, Ying-Bei, Reuter, Victor E, Sander, Chris, Kennedy, Scott R, Hsieh, James J, Lyssiotis, Costas A, Tickoo, Satish K, Hakimi, A Ari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459676/
https://www.ncbi.nlm.nih.gov/pubmed/30924768
http://dx.doi.org/10.7554/eLife.38986

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