Cargando…

Specific protein 1(SP1) regulates the epithelial-mesenchymal transition via lysyl oxidase-like 2(LOXL2) in pancreatic ductal adenocarcinoma

Specific protein 1 (SP1) is associated with aggressive behavior, invasive clinical phenotype and poor clinical outcomes in various cancers. We studied whether SP1 exerts its effect on invasiveness and promotion of the epithelial-mesenchymal transition (EMT) by regulating lysyl oxidase-like 2 (LOXL2)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Im-kyung, Lee, Yun Sun, Kim, Hyung Sun, Dong, Seung Myung, Park, Joon Seong, Yoon, Dong Sup
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459819/ https://www.ncbi.nlm.nih.gov/pubmed/30976063 http://dx.doi.org/10.1038/s41598-019-42501-6

Ejemplares similares

Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin
por: Schmelzer, Christian E. H., et al.
Publicado: (2019)

Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state
por: Zhang, Xi, et al.
Publicado: (2018)

Emerging role of LOXL2 in the promotion of pancreas cancer metastasis
por: Park, Joon Seong, et al.
Publicado: (2016)

Lysyl oxidase-like protein 1 (LOXL1) gene polymorphisms and exfoliation glaucoma in a Central European population
por: Mossböck, Georg, et al.
Publicado: (2008)

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
por: Ikenaga, Naoki, et al.
Publicado: (2017)

2-Aminomethylene-5-sulfonylthiazole Inhibitors of Lysyl Oxidase (LOX) and LOXL2 Show Significant Efficacy in Delaying Tumor Growth
por: Smithen, Deborah A., et al.
Publicado: (2019)

Is Neoadjuvant Treatment Justified in Clinical T1 Pancreatic Ductal Adenocarcinoma?
por: Kim, Hyung Sun, et al.
Publicado: (2021)

Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer()
por: Altuntaş, Ozan Muzaffer, et al.
Publicado: (2021)

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas
por: Moreno-Bueno, Gema, et al.
Publicado: (2011)

Changes in Circulating Lysyl Oxidase-Like-2 (LOXL2) Levels, HOMA, and Fibrosis after Sustained Virological Response by Direct Antiviral Therapy
por: Puente, Angela, et al.
Publicado: (2019)

Lysyl oxidase-like 1-antisense 1 (LOXL1-AS1) lncRNA differentially regulates gene and protein expression, signaling and morphology of human ocular cells
por: Schmitt, Heather M, et al.
Publicado: (2023)

The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins
por: Vallet, Sylvain D., et al.
Publicado: (2020)

Multifunctional Lysyl Oxidases
por: Trackman, Philip C.
Publicado: (2023)

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution
por: Le Calvé, Benjamin, et al.
Publicado: (2016)

Variations in LOXL1 associated with exfoliation glaucoma do not affect amine oxidase activity
por: Kim, Seonkwan, et al.
Publicado: (2012)

Origin and evolution of lysyl oxidases
por: Grau-Bové, Xavier, et al.
Publicado: (2015)

Lysyl Oxidase and the Tumor Microenvironment
por: Wang, Tong-Hong, et al.
Publicado: (2016)

Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma
por: Alonso-Nocelo, Marta, et al.
Publicado: (2023)

Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma
por: Liu, Yang, et al.
Publicado: (2012)

An in situ activity assay for lysyl oxidases
por: Wang, Huilei, et al.
Publicado: (2021)

Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population
por: Kumari, Suchitra, et al.
Publicado: (2021)

Oligomeric States and Hydrodynamic Properties of Lysyl Oxidase-Like 2
por: Meier, Alex A., et al.
Publicado: (2021)

Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-β/collagen pathway in preeclampsia
por: Xu, Xiang-Hong, et al.
Publicado: (2019)

Serum lysyl oxidase concentration increases in long-standing systemic sclerosis: Can lysyl oxidase change over time?
por: Jokar, Mohammad Hassan, et al.
Publicado: (2021)

Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes
por: Liburkin-Dan, Tatyana, et al.
Publicado: (2022)

A 3D–Predicted Structure of the Amine Oxidase Domain of Lysyl Oxidase–Like 2
por: Meier, Alex A., et al.
Publicado: (2022)

Targeting lysyl oxidase reduces peritoneal fibrosis
por: Harlow, Christopher R., et al.
Publicado: (2017)

Fibrosis in Mesothelioma: Potential Role of Lysyl Oxidases
por: Perryman, Lara, et al.
Publicado: (2022)

Retraction: Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma
Publicado: (2022)

Clinical relevance of lysyl oxidase-like 2 and functional mechanisms in glioma
por: Du, Xiao-Guang, et al.
Publicado: (2018)

Mass Spectrometry-Based Disulfide Mapping of Lysyl Oxidase-like 2
por: Meier, Alex A., et al.
Publicado: (2022)

Inhibition of Lysyl Oxidase and Lysyl Oxidase-Like Enzymes Has Tumour-Promoting and Tumour-Suppressing Roles in Experimental Prostate Cancer
por: Nilsson, Maria, et al.
Publicado: (2016)

Effect of Lysyl Oxidase G473A Polymorphism on Lysyl Oxidase and Total Soluble Collagen Expression in Oral Submucous Fibrosis
por: Mukherjee, Sanjit, et al.
Publicado: (2021)

Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis
por: Park, Pil-Gu, et al.
Publicado: (2017)

RKIP and HMGA2 regulate breast tumor survival and metastasis through Lysyl Oxidase and Syndecan-2
por: Sun, Miao, et al.
Publicado: (2013)

Association of lysyl oxidase-like 1 gene polymorphisms with exfoliation syndrome in Koreans
por: Sagong, Min, et al.
Publicado: (2011)

Lysyl oxidase and hypoxia-inducible factor 1α: biomarkers of gastric cancer
por: Han, Ya-Lin, et al.
Publicado: (2019)

Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy
por: Stangenberg, Stefanie, et al.
Publicado: (2018)

Clinical Implications of Lysyl Oxidase-Like Protein 2 Expression in Pancreatic Cancer
por: Tanaka, Nobutake, et al.
Publicado: (2018)

Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling
por: Ramis, Jopeth, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_03mlrj1tfhjfnmm5n0ol36i4us