A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer. However, the reason STAG2 mutations are selec...

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Detalles Bibliográficos
Autores principales: Mondal, Gourish, Stevers, Meredith, Goode, Benjamin, Ashworth, Alan, Solomon, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459917/
https://www.ncbi.nlm.nih.gov/pubmed/30975996
http://dx.doi.org/10.1038/s41467-019-09659-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459917/
https://www.ncbi.nlm.nih.gov/pubmed/30975996
http://dx.doi.org/10.1038/s41467-019-09659-z

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