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A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer. However, the reason STAG2 mutations are selec...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459917/ https://www.ncbi.nlm.nih.gov/pubmed/30975996 http://dx.doi.org/10.1038/s41467-019-09659-z |