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The endocytic trafficking pathway of oncogenic papillomaviruses

Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platfor...

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Autores principales: Mikuličić, Snježana, Florin, Luise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460326/
https://www.ncbi.nlm.nih.gov/pubmed/30946955
http://dx.doi.org/10.1016/j.pvr.2019.03.004
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author Mikuličić, Snježana
Florin, Luise
author_facet Mikuličić, Snježana
Florin, Luise
author_sort Mikuličić, Snježana
collection PubMed
description Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platform. It has been shown that the virus-associated entry complex consists of membrane organizers, tetraspanins CD151 and CD63, and their associated partner proteins such as integrins, growth factor receptors, and the annexin A2 heterotetramer. Further recruitment of cytoplasmic factors such as the obscurin-like protein 1 and actin results in a non-canonical clathrin-independent endocytosis of the virus. Internalized viruses are then routed to multivesicular bodies for capsid disassembly. This early trafficking again involves annexins, and tetraspanin proteins. In this review, we summarize the current knowledge about HPV16 endocytosis and the subsequent endosomal trafficking. Moreover, we propose a model on how tetraspanins and annexins organize the spatial accumulation of HPV16-associated molecules, the recruitment of cytoplasmic trafficking factors, and the L2 membrane penetration to trigger virus entry.
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spelling pubmed-64603262019-04-22 The endocytic trafficking pathway of oncogenic papillomaviruses Mikuličić, Snježana Florin, Luise Papillomavirus Res Article Over the last two decades many host cell proteins have been described to be involved in the process of infectious entry of oncogenic human papillomaviruses (HPV). After initial binding and priming of the capsid, a sequence of events on the cell surface precedes the formation of the HPV entry platform. It has been shown that the virus-associated entry complex consists of membrane organizers, tetraspanins CD151 and CD63, and their associated partner proteins such as integrins, growth factor receptors, and the annexin A2 heterotetramer. Further recruitment of cytoplasmic factors such as the obscurin-like protein 1 and actin results in a non-canonical clathrin-independent endocytosis of the virus. Internalized viruses are then routed to multivesicular bodies for capsid disassembly. This early trafficking again involves annexins, and tetraspanin proteins. In this review, we summarize the current knowledge about HPV16 endocytosis and the subsequent endosomal trafficking. Moreover, we propose a model on how tetraspanins and annexins organize the spatial accumulation of HPV16-associated molecules, the recruitment of cytoplasmic trafficking factors, and the L2 membrane penetration to trigger virus entry. Elsevier 2019-04-01 /pmc/articles/PMC6460326/ /pubmed/30946955 http://dx.doi.org/10.1016/j.pvr.2019.03.004 Text en © 2019 The Authors. Published by Elsevier B.V. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mikuličić, Snježana
Florin, Luise
The endocytic trafficking pathway of oncogenic papillomaviruses
title The endocytic trafficking pathway of oncogenic papillomaviruses
title_full The endocytic trafficking pathway of oncogenic papillomaviruses
title_fullStr The endocytic trafficking pathway of oncogenic papillomaviruses
title_full_unstemmed The endocytic trafficking pathway of oncogenic papillomaviruses
title_short The endocytic trafficking pathway of oncogenic papillomaviruses
title_sort endocytic trafficking pathway of oncogenic papillomaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460326/
https://www.ncbi.nlm.nih.gov/pubmed/30946955
http://dx.doi.org/10.1016/j.pvr.2019.03.004
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