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Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1

Inhibitors of Apoptosis Proteins (IAPs) are conserved E3‐ligases that ubiquitylate substrates to prevent apoptosis and activate the NF‐kB survival pathway, often deregulated in cancer. IAPs‐mediated regulation of NF‐kB signaling is based on the formation of protein complexes by their type‐I BIR doma...

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Detalles Bibliográficos
Autores principales:	Sorrentino, Luca, Cossu, Federica, Milani, Mario, Malkoc, Bilge, Huang, Wen‐Chieh, Tsay, Shwu‐Chen, Ru Hwu, Jih, Mastrangelo, Eloise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460348/ https://www.ncbi.nlm.nih.gov/pubmed/31011505 http://dx.doi.org/10.1002/open.201900059

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