Cargando…

NrCAM is a marker for substrate‐selective activation of ADAM10 in Alzheimer's disease

The metalloprotease ADAM10 is a drug target in Alzheimer's disease, where it cleaves the amyloid precursor protein (APP) and lowers amyloid‐beta. Yet, ADAM10 has additional substrates, which may cause mechanism‐based side effects upon therapeutic ADAM10 activation. However, they may also serve—...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brummer, Tobias, Müller, Stephan A, Pan‐Montojo, Francisco, Yoshida, Fumiaki, Fellgiebel, Andreas, Tomita, Taisuke, Endres, Kristina, Lichtenthaler, Stefan F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460357/ https://www.ncbi.nlm.nih.gov/pubmed/30833305 http://dx.doi.org/10.15252/emmm.201809695

Ejemplares similares

Cataracts and NrCAM
por: Dove, Alan W.
Publicado: (2001)

Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites
Publicado: (1996)

NrCAM modulates sonic hedgehog signalling by controlling smoothened translocation in the cilium
por: Basu, B, et al.
Publicado: (2015)

CHL1 and NrCAM are Primarily Expressed in Low Grade Pediatric Neuroblastoma
por: Wachowiak, Robin, et al.
Publicado: (2019)

NrCAM, a neuronal system cell-adhesion molecule, is induced in papillary thyroid carcinomas
por: Górka, B, et al.
Publicado: (2007)

Neuron Glia-Related Cell Adhesion Molecule (NrCAM) Promotes Topographic Retinocollicular Mapping
por: Dai, Jinxia, et al.
Publicado: (2013)

Expression and Function of Neuron-Glia-Related Cell Adhesion Molecule (NrCAM) in the Amygdalar Pathway
por: Mohan, Vishwa, et al.
Publicado: (2019)

Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation
por: Moré, Margret I., et al.
Publicado: (2001)

Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons
por: Mohan, Vishwa, et al.
Publicado: (2018)

Association of the Neuronal Cell Adhesion Molecule (NrCAM) Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder
por: Yoo, Byung Kuk, et al.
Publicado: (2012)

Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes
por: Moore, Alex, et al.
Publicado: (2022)

NrCAM secreted by endometrial stromal cells enhances the progestin sensitivity of endometrial cancer cells through epigenetic modulation of PRB
por: Cheng, Yali, et al.
Publicado: (2022)

Molecular composition of the node of Ranvier: identification of ankyrin- binding cell adhesion molecules neurofascin (mucin+/third FNIII domain- ) and NrCAM at nodal axon segments
Publicado: (1996)

The Potential Role of Serum Tau Protein (MAPT), Neuronal Cell Adhesion Molecule (NrCAM) and Neprilysin (NEP) in Neurodegenerative Disorders Development in Psoriasis—Preliminary Results
por: Baran, Anna, et al.
Publicado: (2022)

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
por: Augustin, Regina, et al.
Publicado: (2012)

miR-505 suppresses prostate cancer progression by targeting NRCAM
por: Ling, Xiao-Hui, et al.
Publicado: (2019)

miR-505 suppresses prostate cancer progression by targeting NRCAM
por: Ling, Xiao-Hui, et al.
Publicado: (2020)

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
por: Prinzen, Claudia, et al.
Publicado: (2009)

Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics
por: Calligaris, Matteo, et al.
Publicado: (2023)

Mapping of pituitary stress-induced gene regulation connects Nrcam to negative emotions
por: Olsen, Maria Belland, et al.
Publicado: (2022)

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
por: Schlepckow, Kai, et al.
Publicado: (2017)

Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor
por: Scilabra, Simone D., et al.
Publicado: (2018)

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
por: Kuhn, Peer-Hendrik, et al.
Publicado: (2016)

Proteomic Substrate Identification for Membrane Proteases in the Brain
por: Müller, Stephan A., et al.
Publicado: (2016)

Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes
por: Hutcheson, Holli B, et al.
Publicado: (2004)

Liver cancer stem cell dissemination and metastasis: uncovering the role of NRCAM in hepatocellular carcinoma
por: Zhou, Lingyun, et al.
Publicado: (2023)

TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2)
por: Chemaly, Melody, et al.
Publicado: (2022)

Apolipoprotein A1 in Cerebrospinal Fluid Is Insufficient to Distinguish Alzheimer’s Disease from Other Dementias in a Naturalistic, Clinical Setting
por: Stoye, Nicolai Maximilian, et al.
Publicado: (2020)

The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients
por: dos Santos Guilherme, Malena, et al.
Publicado: (2019)

Quantitative Proteomics Reveals That ADAM15 Can Have Proteolytic-Independent Functions in the Steady State
por: Yang, Chun-Yao, et al.
Publicado: (2022)

Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms
por: Endres, Kristina, et al.
Publicado: (2017)

Bravo/Nr-CAM is closely related to the cell adhesion molecules L1 and Ng-CAM and has a similar heterodimer structure
Publicado: (1992)

KLF9 regulates miR-338-3p/NRCAM axis to block the progression of osteosarcoma cells
por: Liu, Yunlu, et al.
Publicado: (2022)

Bi‐allelic loss of function variant in the NRCAM gene is associated with motor‐predominant axonal polyneuropathy; the second report
por: Elahi, Zohreh, et al.
Publicado: (2023)

Homophilic and heterophilic binding activities of Nr-CAM, a nervous system cell adhesion molecule
Publicado: (1992)

Overlapping functions of the cell adhesion molecules Nr-CAM and L1 in cerebellar granule cell development
por: Sakurai, Takeshi, et al.
Publicado: (2001)

ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion
por: Jocher, Georg, et al.
Publicado: (2022)

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
por: Madoux, Franck, et al.
Publicado: (2016)

Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants
por: Meineck, Myriam, et al.
Publicado: (2016)

Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase
por: Lichtenthaler, Stefan
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9rd74eug7j8gvpfe9rofjdhteq