A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification

The balance between stem cell maintenance and differentiation has been proposed to depend on antagonizing ubiquitination and deubiquitination reactions of key stem cell transcription factors (SCTFs) mediated by pairs of E3 ubiquitin ligases and deubiquitinating enzymes. Accordingly, increased ubiqui...

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Detalles Bibliográficos
Autores principales: Nicklas, Sarah, Hillje, Anna-Lena, Okawa, Satoshi, Rudolph, Ina-Maria, Collmann, Franziska Melanie, van Wuellen, Thea, del Sol, Antonio, Schwamborn, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460386/
https://www.ncbi.nlm.nih.gov/pubmed/29899379
http://dx.doi.org/10.1038/s41418-018-0144-1

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