Pathogenesis of and major animal models used for nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) and its pathologically more severe form, nonalcoholic steatohepatitis (NASH), have become prevalent worldwide and carry an increased risk of developing hepatocellular carcinoma and other metabolic diseases. Diverse animal models have been proposed to replicat...

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Autores principales: Jiang, Mingzuo, Wu, Nan, Chen, Xi, Wang, Weijie, Chu, Yi, Liu, Hao, Li, Wenjiao, Chen, Di, Li, Xiaowei, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460620/
https://www.ncbi.nlm.nih.gov/pubmed/30871397
http://dx.doi.org/10.1177/0300060519833527
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author Jiang, Mingzuo
Wu, Nan
Chen, Xi
Wang, Weijie
Chu, Yi
Liu, Hao
Li, Wenjiao
Chen, Di
Li, Xiaowei
Xu, Bing
author_facet Jiang, Mingzuo
Wu, Nan
Chen, Xi
Wang, Weijie
Chu, Yi
Liu, Hao
Li, Wenjiao
Chen, Di
Li, Xiaowei
Xu, Bing
author_sort Jiang, Mingzuo
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) and its pathologically more severe form, nonalcoholic steatohepatitis (NASH), have become prevalent worldwide and carry an increased risk of developing hepatocellular carcinoma and other metabolic diseases. Diverse animal models have been proposed to replicate particular characteristics of NAFLD and NASH and have provided significant clues to the critical molecular targets of NASH treatment. In this review, we summarize the histopathology, pathogenesis, and molecular basis of NAFLD progression and discuss the benchmark animal models of NAFLD/NASH.
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spelling pubmed-64606202019-04-19 Pathogenesis of and major animal models used for nonalcoholic fatty liver disease Jiang, Mingzuo Wu, Nan Chen, Xi Wang, Weijie Chu, Yi Liu, Hao Li, Wenjiao Chen, Di Li, Xiaowei Xu, Bing J Int Med Res Reviews Nonalcoholic fatty liver disease (NAFLD) and its pathologically more severe form, nonalcoholic steatohepatitis (NASH), have become prevalent worldwide and carry an increased risk of developing hepatocellular carcinoma and other metabolic diseases. Diverse animal models have been proposed to replicate particular characteristics of NAFLD and NASH and have provided significant clues to the critical molecular targets of NASH treatment. In this review, we summarize the histopathology, pathogenesis, and molecular basis of NAFLD progression and discuss the benchmark animal models of NAFLD/NASH. SAGE Publications 2019-03-15 2019-04 /pmc/articles/PMC6460620/ /pubmed/30871397 http://dx.doi.org/10.1177/0300060519833527 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Jiang, Mingzuo
Wu, Nan
Chen, Xi
Wang, Weijie
Chu, Yi
Liu, Hao
Li, Wenjiao
Chen, Di
Li, Xiaowei
Xu, Bing
Pathogenesis of and major animal models used for nonalcoholic fatty liver disease
title Pathogenesis of and major animal models used for nonalcoholic fatty liver disease
title_full Pathogenesis of and major animal models used for nonalcoholic fatty liver disease
title_fullStr Pathogenesis of and major animal models used for nonalcoholic fatty liver disease
title_full_unstemmed Pathogenesis of and major animal models used for nonalcoholic fatty liver disease
title_short Pathogenesis of and major animal models used for nonalcoholic fatty liver disease
title_sort pathogenesis of and major animal models used for nonalcoholic fatty liver disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460620/
https://www.ncbi.nlm.nih.gov/pubmed/30871397
http://dx.doi.org/10.1177/0300060519833527
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