Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?

HPV related OPSCC has a distinct behavior and improved outcome. As immunotherapy has recently evolved into a new standard for advanced (SCCHN), trials for high-risk SCCHN have trended to encompass both HPV related and unrelated diseases. In this invited editorial, we question the wisdom of this appr...

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Autores principales: Saba, Nabil F, Li, Shuli, Hussain, Zain A, Subramanian, Rathan, Califano, Joseph A, Chung, Christine H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460663/
https://www.ncbi.nlm.nih.gov/pubmed/31093361
http://dx.doi.org/10.1186/s41199-018-0035-7
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author Saba, Nabil F
Li, Shuli
Hussain, Zain A
Subramanian, Rathan
Califano, Joseph A
Chung, Christine H
author_facet Saba, Nabil F
Li, Shuli
Hussain, Zain A
Subramanian, Rathan
Califano, Joseph A
Chung, Christine H
author_sort Saba, Nabil F
collection PubMed
description HPV related OPSCC has a distinct behavior and improved outcome. As immunotherapy has recently evolved into a new standard for advanced (SCCHN), trials for high-risk SCCHN have trended to encompass both HPV related and unrelated diseases. In this invited editorial, we question the wisdom of this approach and argue for the design of trials focused specifically on HPV related locally advanced oropharyngeal squamous cell carcinoma as a unique disease entity.
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spelling pubmed-64606632019-05-15 Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease? Saba, Nabil F Li, Shuli Hussain, Zain A Subramanian, Rathan Califano, Joseph A Chung, Christine H Cancers Head Neck Editorial HPV related OPSCC has a distinct behavior and improved outcome. As immunotherapy has recently evolved into a new standard for advanced (SCCHN), trials for high-risk SCCHN have trended to encompass both HPV related and unrelated diseases. In this invited editorial, we question the wisdom of this approach and argue for the design of trials focused specifically on HPV related locally advanced oropharyngeal squamous cell carcinoma as a unique disease entity. BioMed Central 2018-10-03 /pmc/articles/PMC6460663/ /pubmed/31093361 http://dx.doi.org/10.1186/s41199-018-0035-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Editorial
Saba, Nabil F
Li, Shuli
Hussain, Zain A
Subramanian, Rathan
Califano, Joseph A
Chung, Christine H
Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?
title Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?
title_full Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?
title_fullStr Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?
title_full_unstemmed Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?
title_short Locally advanced high-risk HPV related oropharyngeal squamous cell carcinoma (OPSCC); have we forgotten it is a different disease?
title_sort locally advanced high-risk hpv related oropharyngeal squamous cell carcinoma (opscc); have we forgotten it is a different disease?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460663/
https://www.ncbi.nlm.nih.gov/pubmed/31093361
http://dx.doi.org/10.1186/s41199-018-0035-7
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