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Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

BACKGROUND: 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment in colorectal cancer in vitro. METHODS: SW480 cells were in the present study a...

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Detalles Bibliográficos
Autores principales:	Yao, Weilong, Zhu, Shengtao, Li, Peng, Zhang, Shutian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460675/ https://www.ncbi.nlm.nih.gov/pubmed/31011291 http://dx.doi.org/10.1186/s12935-019-0812-3

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