HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis

Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HP...

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Detalles Bibliográficos
Autores principales: Pan, Cassie, Issaeva, Natalia, Yarbrough, Wendell G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460765/
https://www.ncbi.nlm.nih.gov/pubmed/31093365
http://dx.doi.org/10.1186/s41199-018-0039-3
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author Pan, Cassie
Issaeva, Natalia
Yarbrough, Wendell G.
author_facet Pan, Cassie
Issaeva, Natalia
Yarbrough, Wendell G.
author_sort Pan, Cassie
collection PubMed
description Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HPV+ oropharyngeal cancer, further investigation and characterization the unique features of the disease, along with the development and implementation of new, targeted therapies, is crucial. In this review, we summarize the etiology, pathogenesis, diagnosis, treatment, and molecular characteristics of HPV-associated oropharyngeal squamous cell carcinoma.
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spelling pubmed-64607652019-05-15 HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis Pan, Cassie Issaeva, Natalia Yarbrough, Wendell G. Cancers Head Neck Review Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HPV+ oropharyngeal cancer, further investigation and characterization the unique features of the disease, along with the development and implementation of new, targeted therapies, is crucial. In this review, we summarize the etiology, pathogenesis, diagnosis, treatment, and molecular characteristics of HPV-associated oropharyngeal squamous cell carcinoma. BioMed Central 2018-12-29 /pmc/articles/PMC6460765/ /pubmed/31093365 http://dx.doi.org/10.1186/s41199-018-0039-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Pan, Cassie
Issaeva, Natalia
Yarbrough, Wendell G.
HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
title HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
title_full HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
title_fullStr HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
title_full_unstemmed HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
title_short HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
title_sort hpv-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460765/
https://www.ncbi.nlm.nih.gov/pubmed/31093365
http://dx.doi.org/10.1186/s41199-018-0039-3
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