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Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation

BACKGROUND: Extracellular high mobility group box 1 protein (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products (RAGE). These pro-inflammatory complexes are ta...

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Detalles Bibliográficos
Autores principales:	Yang, Huan, Liu, Hui, Zeng, Qiong, Imperato, Gavin H., Addorisio, Meghan E., Li, Jianhua, He, Mingzhu, Cheng, Kai Fan, Al-Abed, Yousef, Harris, Helena E., Chavan, Sangeeta S., Andersson, Ulf, Tracey, Kevin J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460792/ https://www.ncbi.nlm.nih.gov/pubmed/30975096 http://dx.doi.org/10.1186/s10020-019-0081-6

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