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Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation
Heart failure affects 1–2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30–50%, mortality rates remain high. A complex blend of structural and functi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460884/ https://www.ncbi.nlm.nih.gov/pubmed/31007907 http://dx.doi.org/10.1177/2048004019843047 |
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author | Giannitsi, Sofia Bougiakli, Maria Bechlioulis, Aris Naka, Katerina |
author_facet | Giannitsi, Sofia Bougiakli, Maria Bechlioulis, Aris Naka, Katerina |
author_sort | Giannitsi, Sofia |
collection | PubMed |
description | Heart failure affects 1–2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30–50%, mortality rates remain high. A complex blend of structural and functional alterations accounts for the genesis and progression of heart failure, but the exact underlying pathophysiology remains poorly understood. The aim of this review is to summarize endothelial dysfunction and its role in the pathogenesis and progression of heart failure. Moreover, it sums up all the appropriate methods of assessing endothelial dysfunction emphasizing on flow-mediated dilation and introduces endothelium as a potential target for new therapeutic development and research in the wide spectrum of the syndrome called heart failure. |
format | Online Article Text |
id | pubmed-6460884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-64608842019-04-19 Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation Giannitsi, Sofia Bougiakli, Maria Bechlioulis, Aris Naka, Katerina JRSM Cardiovasc Dis Review Article Heart failure affects 1–2% of the population worldwide, and it is characterized by episodes of decompensation often requiring hospitalization. Although targeted treatment has reduced the prevalence of rehospitalizations to 30–50%, mortality rates remain high. A complex blend of structural and functional alterations accounts for the genesis and progression of heart failure, but the exact underlying pathophysiology remains poorly understood. The aim of this review is to summarize endothelial dysfunction and its role in the pathogenesis and progression of heart failure. Moreover, it sums up all the appropriate methods of assessing endothelial dysfunction emphasizing on flow-mediated dilation and introduces endothelium as a potential target for new therapeutic development and research in the wide spectrum of the syndrome called heart failure. SAGE Publications 2019-04-11 /pmc/articles/PMC6460884/ /pubmed/31007907 http://dx.doi.org/10.1177/2048004019843047 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Article Giannitsi, Sofia Bougiakli, Maria Bechlioulis, Aris Naka, Katerina Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation |
title | Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation |
title_full | Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation |
title_fullStr | Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation |
title_full_unstemmed | Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation |
title_short | Endothelial dysfunction and heart failure: A review of the existing bibliography with emphasis on flow mediated dilation |
title_sort | endothelial dysfunction and heart failure: a review of the existing bibliography with emphasis on flow mediated dilation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460884/ https://www.ncbi.nlm.nih.gov/pubmed/31007907 http://dx.doi.org/10.1177/2048004019843047 |
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