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Defending Our Public Biological Databases as a Global Critical Infrastructure
Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) information. INSDC and similar d...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460893/ https://www.ncbi.nlm.nih.gov/pubmed/31024904 http://dx.doi.org/10.3389/fbioe.2019.00058 |
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author | Caswell, Jacob Gans, Jason D. Generous, Nicholas Hudson, Corey M. Merkley, Eric Johnson, Curtis Oehmen, Christopher Omberg, Kristin Purvine, Emilie Taylor, Karen Ting, Christina L. Wolinsky, Murray Xie, Gary |
author_facet | Caswell, Jacob Gans, Jason D. Generous, Nicholas Hudson, Corey M. Merkley, Eric Johnson, Curtis Oehmen, Christopher Omberg, Kristin Purvine, Emilie Taylor, Karen Ting, Christina L. Wolinsky, Murray Xie, Gary |
author_sort | Caswell, Jacob |
collection | PubMed |
description | Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) information. INSDC and similar databases have dramatically increased the pace of fundamental biological discovery and enabled a host of innovative therapeutic, diagnostic, and forensic applications. However, as high-value, openly shared resources with a high degree of assumed trust, these repositories share compelling similarities to the early days of the Internet. Consequently, as public biological databases continue to increase in size and importance, we expect that they will face the same threats as undefended cyberspace. There is a unique opportunity, before a significant breach and loss of trust occurs, to ensure they evolve with quality and security as a design philosophy rather than costly “retrofitted” mitigations. This Perspective surveys some potential quality assurance and security weaknesses in existing open genomic and proteomic repositories, describes methods to mitigate the likelihood of both intentional and unintentional errors, and offers recommendations for risk mitigation based on lessons learned from cybersecurity. |
format | Online Article Text |
id | pubmed-6460893 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64608932019-04-25 Defending Our Public Biological Databases as a Global Critical Infrastructure Caswell, Jacob Gans, Jason D. Generous, Nicholas Hudson, Corey M. Merkley, Eric Johnson, Curtis Oehmen, Christopher Omberg, Kristin Purvine, Emilie Taylor, Karen Ting, Christina L. Wolinsky, Murray Xie, Gary Front Bioeng Biotechnol Bioengineering and Biotechnology Progress in modern biology is being driven, in part, by the large amounts of freely available data in public resources such as the International Nucleotide Sequence Database Collaboration (INSDC), the world's primary database of biological sequence (and related) information. INSDC and similar databases have dramatically increased the pace of fundamental biological discovery and enabled a host of innovative therapeutic, diagnostic, and forensic applications. However, as high-value, openly shared resources with a high degree of assumed trust, these repositories share compelling similarities to the early days of the Internet. Consequently, as public biological databases continue to increase in size and importance, we expect that they will face the same threats as undefended cyberspace. There is a unique opportunity, before a significant breach and loss of trust occurs, to ensure they evolve with quality and security as a design philosophy rather than costly “retrofitted” mitigations. This Perspective surveys some potential quality assurance and security weaknesses in existing open genomic and proteomic repositories, describes methods to mitigate the likelihood of both intentional and unintentional errors, and offers recommendations for risk mitigation based on lessons learned from cybersecurity. Frontiers Media S.A. 2019-04-05 /pmc/articles/PMC6460893/ /pubmed/31024904 http://dx.doi.org/10.3389/fbioe.2019.00058 Text en Copyright © 2019 Caswell, Gans, Generous, Hudson, Merkley, Johnson, Oehmen, Omberg, Purvine, Taylor, Ting, Wolinsky and Xie. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Caswell, Jacob Gans, Jason D. Generous, Nicholas Hudson, Corey M. Merkley, Eric Johnson, Curtis Oehmen, Christopher Omberg, Kristin Purvine, Emilie Taylor, Karen Ting, Christina L. Wolinsky, Murray Xie, Gary Defending Our Public Biological Databases as a Global Critical Infrastructure |
title | Defending Our Public Biological Databases as a Global Critical Infrastructure |
title_full | Defending Our Public Biological Databases as a Global Critical Infrastructure |
title_fullStr | Defending Our Public Biological Databases as a Global Critical Infrastructure |
title_full_unstemmed | Defending Our Public Biological Databases as a Global Critical Infrastructure |
title_short | Defending Our Public Biological Databases as a Global Critical Infrastructure |
title_sort | defending our public biological databases as a global critical infrastructure |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460893/ https://www.ncbi.nlm.nih.gov/pubmed/31024904 http://dx.doi.org/10.3389/fbioe.2019.00058 |
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