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Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination
BACKGROUND: The aim of this study was to determine the risk factors for early chronic kidney disease (CKD) (GFR 60–89 ml/min/1.73 m(2); CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination. MATERIAL/METHODS: This cross-sectional study enrolled 9100 individuals who r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461005/ https://www.ncbi.nlm.nih.gov/pubmed/30944297 http://dx.doi.org/10.12659/MSM.913506 |
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author | Xue, Ning Fang, Yi Ding, Xiaoqiang Wang, Li Xu, Linghan Jiang, Xiaotian Zhang, Xiaoyan |
author_facet | Xue, Ning Fang, Yi Ding, Xiaoqiang Wang, Li Xu, Linghan Jiang, Xiaotian Zhang, Xiaoyan |
author_sort | Xue, Ning |
collection | PubMed |
description | BACKGROUND: The aim of this study was to determine the risk factors for early chronic kidney disease (CKD) (GFR 60–89 ml/min/1.73 m(2); CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination. MATERIAL/METHODS: This cross-sectional study enrolled 9100 individuals who received voluntary medical examinations between 10/01/2011 and 09/30/2017. Demographic data, clinical history, clinical examination, medication, smoking, alcohol, blood biochemistry, urinalysis, and carotid ultrasound were extracted from the medical records. All laboratory analyses were performed routinely. Multivariable logistic regression for factors predicting CKD stage 2 was performed. RESULT: A total of 9100 individuals were enrolled (age of 18–65 and 65.4% male). CKD stage 2 was found in 1989/9100 individuals (21.9%). Male gender (OR=6.711, 95%CI: 5.376–8.403, P<0.001), older age (OR=1.077, 95%CI: 1.068–1.086, P<0.001), hemoglobin levels (OR=1.051, 95%CI: 1.046–1.057, P<0.001), triglycerides levels (OR=1.174, 95%CI: 1.067–1.292, P=0.001), HDL-C (OR=0.539, 95%CI: 0.380–0.763, P<0.001), Lp(a) levels (OR=1.000, 95%CI: 1.000–1.001, P=0.03), and carotid atherosclerosis (OR=1.248, 95%CI: 1.005–1.550, P=0.045) were associated with CKD stage 2 among all subjects. Serum triglycerides levels were associated with CKD stage 2 in the 18–45 and 45–65 years of age subgroups. CONCLUSIONS: Factors that are routinely assessed during routine health examinations (male gender, age, hemoglobin levels, triglycerides levels, HDL-C, Lp(a) levels, and carotid atherosclerosis) can help identify individuals at higher risk of having CKD stage 2. The Chinese dyslipidemia is characterized by high triglycerides and low HDL-C and occurs in young and middle-aged individuals. Those factors could help identify individuals at higher risk for CKD stage 2 and who could benefit from preventive treatments. |
format | Online Article Text |
id | pubmed-6461005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64610052019-04-26 Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination Xue, Ning Fang, Yi Ding, Xiaoqiang Wang, Li Xu, Linghan Jiang, Xiaotian Zhang, Xiaoyan Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to determine the risk factors for early chronic kidney disease (CKD) (GFR 60–89 ml/min/1.73 m(2); CKD stage 2) in asymptomatic Chinese individuals undergoing routine health examination. MATERIAL/METHODS: This cross-sectional study enrolled 9100 individuals who received voluntary medical examinations between 10/01/2011 and 09/30/2017. Demographic data, clinical history, clinical examination, medication, smoking, alcohol, blood biochemistry, urinalysis, and carotid ultrasound were extracted from the medical records. All laboratory analyses were performed routinely. Multivariable logistic regression for factors predicting CKD stage 2 was performed. RESULT: A total of 9100 individuals were enrolled (age of 18–65 and 65.4% male). CKD stage 2 was found in 1989/9100 individuals (21.9%). Male gender (OR=6.711, 95%CI: 5.376–8.403, P<0.001), older age (OR=1.077, 95%CI: 1.068–1.086, P<0.001), hemoglobin levels (OR=1.051, 95%CI: 1.046–1.057, P<0.001), triglycerides levels (OR=1.174, 95%CI: 1.067–1.292, P=0.001), HDL-C (OR=0.539, 95%CI: 0.380–0.763, P<0.001), Lp(a) levels (OR=1.000, 95%CI: 1.000–1.001, P=0.03), and carotid atherosclerosis (OR=1.248, 95%CI: 1.005–1.550, P=0.045) were associated with CKD stage 2 among all subjects. Serum triglycerides levels were associated with CKD stage 2 in the 18–45 and 45–65 years of age subgroups. CONCLUSIONS: Factors that are routinely assessed during routine health examinations (male gender, age, hemoglobin levels, triglycerides levels, HDL-C, Lp(a) levels, and carotid atherosclerosis) can help identify individuals at higher risk of having CKD stage 2. The Chinese dyslipidemia is characterized by high triglycerides and low HDL-C and occurs in young and middle-aged individuals. Those factors could help identify individuals at higher risk for CKD stage 2 and who could benefit from preventive treatments. International Scientific Literature, Inc. 2019-04-04 /pmc/articles/PMC6461005/ /pubmed/30944297 http://dx.doi.org/10.12659/MSM.913506 Text en © Med Sci Monit, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Clinical Research Xue, Ning Fang, Yi Ding, Xiaoqiang Wang, Li Xu, Linghan Jiang, Xiaotian Zhang, Xiaoyan Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination |
title | Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination |
title_full | Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination |
title_fullStr | Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination |
title_full_unstemmed | Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination |
title_short | Serum Triglycerides Are Related to Chronic Kidney Disease (CKD) Stage 2 in Young and Middle-Aged Chinese Individuals During Routine Health Examination |
title_sort | serum triglycerides are related to chronic kidney disease (ckd) stage 2 in young and middle-aged chinese individuals during routine health examination |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461005/ https://www.ncbi.nlm.nih.gov/pubmed/30944297 http://dx.doi.org/10.12659/MSM.913506 |
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