Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape

The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of thi...

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Autores principales: Sakhnevych, Svetlana S., Yasinska, Inna M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461007/
https://www.ncbi.nlm.nih.gov/pubmed/31024310
http://dx.doi.org/10.3389/fphar.2019.00342
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author Sakhnevych, Svetlana S.
Yasinska, Inna M.
Fasler-Kan, Elizaveta
Sumbayev, Vadim V.
author_facet Sakhnevych, Svetlana S.
Yasinska, Inna M.
Fasler-Kan, Elizaveta
Sumbayev, Vadim V.
author_sort Sakhnevych, Svetlana S.
collection PubMed
description The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.
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spelling pubmed-64610072019-04-25 Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape Sakhnevych, Svetlana S. Yasinska, Inna M. Fasler-Kan, Elizaveta Sumbayev, Vadim V. Front Pharmacol Pharmacology The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria. Frontiers Media S.A. 2019-04-05 /pmc/articles/PMC6461007/ /pubmed/31024310 http://dx.doi.org/10.3389/fphar.2019.00342 Text en Copyright © 2019 Sakhnevych, Yasinska, Fasler-Kan and Sumbayev. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Sakhnevych, Svetlana S.
Yasinska, Inna M.
Fasler-Kan, Elizaveta
Sumbayev, Vadim V.
Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
title Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
title_full Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
title_fullStr Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
title_full_unstemmed Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
title_short Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
title_sort mitochondrial defunctionalization supresses tim-3-galectin-9 secretory pathway in human colorectal cancer cells and thus can possibly affect tumor immune escape
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461007/
https://www.ncbi.nlm.nih.gov/pubmed/31024310
http://dx.doi.org/10.3389/fphar.2019.00342
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