Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose)

Telomerase and poly(ADP-ribose) polymerase-1 (PARP-1) are two potential cancer biomarkers and are closely related to tumor initiation and malignant progression. TOTO-1 is well-known for differentiating ss-DNA from ds-DNA because it is virtually non-fluorescent without DNA and exhibits very low fluor...

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Detalles Bibliográficos
Autores principales: Yang, Haitang, Fu, Fangjia, Li, Wei, Wei, Wei, Zhang, Yuanjian, Liu, Songqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461019/
https://www.ncbi.nlm.nih.gov/pubmed/31015914
http://dx.doi.org/10.1039/c8sc05770b

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