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Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota

It is well known that the incidence of postoperative cognitive dysfunction (POCD) is high in elderly patients. The pathogenesis and therapeutic mechanisms of POCD, however, have not yet been completely elucidated. The effects of gut microbiota, particularly in terms of regulating brain function, hav...

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Autores principales: Zhan, Gaofeng, Hua, Dongyu, Huang, Niannian, Wang, Yue, Li, Shan, Zhou, Zhiqiang, Yang, Ning, Jiang, Riyue, Zhu, Bin, Yang, Ling, Yu, Fan, Xu, Hui, Yang, Chun, Luo, Ailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461176/
https://www.ncbi.nlm.nih.gov/pubmed/30904902
http://dx.doi.org/10.18632/aging.101871
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author Zhan, Gaofeng
Hua, Dongyu
Huang, Niannian
Wang, Yue
Li, Shan
Zhou, Zhiqiang
Yang, Ning
Jiang, Riyue
Zhu, Bin
Yang, Ling
Yu, Fan
Xu, Hui
Yang, Chun
Luo, Ailin
author_facet Zhan, Gaofeng
Hua, Dongyu
Huang, Niannian
Wang, Yue
Li, Shan
Zhou, Zhiqiang
Yang, Ning
Jiang, Riyue
Zhu, Bin
Yang, Ling
Yu, Fan
Xu, Hui
Yang, Chun
Luo, Ailin
author_sort Zhan, Gaofeng
collection PubMed
description It is well known that the incidence of postoperative cognitive dysfunction (POCD) is high in elderly patients. The pathogenesis and therapeutic mechanisms of POCD, however, have not yet been completely elucidated. The effects of gut microbiota, particularly in terms of regulating brain function, have gradually attracted increasing attention. In this study, we investigated the potential role of gut microbiota in POCD in aged male mice and attempted to determine whether alterations in gut microbiota would be helpful in the diagnosis of POCD. POCD and non-POCD mice were classified by hierarchical cluster analysis of behavioral results. Additionally, α- and β-diversity of gut microbiota showed a differential profile between the groups. In total, 24 gut bacteria were significantly altered in POCD mice compared with those in non-POCD mice, in which 13 gut bacteria were significantly correlated with escape latency in the Morris water maze test (MWMT). Remarkably, receiver operating characteristic curves revealed that the Dehalobacteriaceae family and Dehalobacterium genus are potentially important bacteria for the diagnosis of POCD. These findings indicate that alterations in the composition of gut microbiota are probably involved in the pathogenesis of POCD in aged mice. Novel therapeutic strategies regulating specific gut bacteria may be helpful for the prevention and treatment of POCD.
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spelling pubmed-64611762019-04-19 Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota Zhan, Gaofeng Hua, Dongyu Huang, Niannian Wang, Yue Li, Shan Zhou, Zhiqiang Yang, Ning Jiang, Riyue Zhu, Bin Yang, Ling Yu, Fan Xu, Hui Yang, Chun Luo, Ailin Aging (Albany NY) Research Paper It is well known that the incidence of postoperative cognitive dysfunction (POCD) is high in elderly patients. The pathogenesis and therapeutic mechanisms of POCD, however, have not yet been completely elucidated. The effects of gut microbiota, particularly in terms of regulating brain function, have gradually attracted increasing attention. In this study, we investigated the potential role of gut microbiota in POCD in aged male mice and attempted to determine whether alterations in gut microbiota would be helpful in the diagnosis of POCD. POCD and non-POCD mice were classified by hierarchical cluster analysis of behavioral results. Additionally, α- and β-diversity of gut microbiota showed a differential profile between the groups. In total, 24 gut bacteria were significantly altered in POCD mice compared with those in non-POCD mice, in which 13 gut bacteria were significantly correlated with escape latency in the Morris water maze test (MWMT). Remarkably, receiver operating characteristic curves revealed that the Dehalobacteriaceae family and Dehalobacterium genus are potentially important bacteria for the diagnosis of POCD. These findings indicate that alterations in the composition of gut microbiota are probably involved in the pathogenesis of POCD in aged mice. Novel therapeutic strategies regulating specific gut bacteria may be helpful for the prevention and treatment of POCD. Impact Journals 2019-03-23 /pmc/articles/PMC6461176/ /pubmed/30904902 http://dx.doi.org/10.18632/aging.101871 Text en Copyright © 2019 Zhan et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Zhan, Gaofeng
Hua, Dongyu
Huang, Niannian
Wang, Yue
Li, Shan
Zhou, Zhiqiang
Yang, Ning
Jiang, Riyue
Zhu, Bin
Yang, Ling
Yu, Fan
Xu, Hui
Yang, Chun
Luo, Ailin
Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
title Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
title_full Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
title_fullStr Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
title_full_unstemmed Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
title_short Anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
title_sort anesthesia and surgery induce cognitive dysfunction in elderly male mice: the role of gut microbiota
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461176/
https://www.ncbi.nlm.nih.gov/pubmed/30904902
http://dx.doi.org/10.18632/aging.101871
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