RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) as toxic cytoplasmic inclusions is one of the hallmarks of these pathologies...

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Detalles Bibliográficos
Autores principales: Zacco, Elsa, Graña-Montes, Ricardo, Martin, Stephen R., de Groot, Natalia Sanchez, Alfano, Caterina, Tartaglia, Gian Gaetano, Pastore, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461199/
https://www.ncbi.nlm.nih.gov/pubmed/30742796
http://dx.doi.org/10.1016/j.jmb.2019.01.028

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