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A new technology for increasing therapeutic protein levels in the brain over extended periods

Effective delivery of protein therapeutics into the brain remains challenging because of difficulties associated with crossing the blood-brain barrier (BBB). To overcome this problem, many researchers have focused on antibodies binding the transferrin receptor (TfR), which is expressed in endothelia...

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Detalles Bibliográficos
Autores principales:	Nakano, Ryosuke, Takagi-Maeda, Sayaka, Ito, Yuji, Kishimoto, Satoshi, Osato, Tomoko, Noguchi, Kaori, Kurihara-Suda, Kana, Takahashi, Nobuaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461266/ https://www.ncbi.nlm.nih.gov/pubmed/30978197 http://dx.doi.org/10.1371/journal.pone.0214404

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