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Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes

Integrins are transmembrane proteins involved in hemostasis, wound healing, immunity and cancer. In response to intracellular signals and ligand binding, integrins adopt different conformations: the bent (resting) form; the intermediate extended form; and the ligand-occupied active form. An integrin...

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Detalles Bibliográficos
Autores principales:	Janke, Una, Kulke, Martin, Buchholz, Ina, Geist, Norman, Langel, Walter, Delcea, Mihaela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461286/ https://www.ncbi.nlm.nih.gov/pubmed/30978226 http://dx.doi.org/10.1371/journal.pone.0214969

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