Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investi...

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Detalles Bibliográficos
Autores principales: Lodge, Emily J, Santambrogio, Alice, Russell, John P, Xekouki, Paraskevi, Jacques, Thomas S, Johnson, Randy L, Thavaraj, Selvam, Bornstein, Stefan R, Andoniadou, Cynthia Lilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Stem Cells and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461440/
https://www.ncbi.nlm.nih.gov/pubmed/30912742
http://dx.doi.org/10.7554/eLife.43996

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