Complement C4 Prevents Viral Infection through Capsid Inactivation

The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r(2)C1s(2)) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering microbial clearance. We demonstrate a C4-dependent antiviral mechanism...

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Detalles Bibliográficos
Autores principales: Bottermann, Maria, Foss, Stian, Caddy, Sarah L., Clift, Dean, van Tienen, Laurens M., Vaysburd, Marina, Cruickshank, James, O’Connell, Kevin, Clark, Jessica, Mayes, Keith, Higginson, Katie, Lode, Heidrun E., McAdam, Martin B., Sandlie, Inger, Andersen, Jan Terje, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461443/
https://www.ncbi.nlm.nih.gov/pubmed/30926239
http://dx.doi.org/10.1016/j.chom.2019.02.016

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