APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors

Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using whole-exome and transcriptome sequencing, SNP array for cop...

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Detalles Bibliográficos
Autores principales: Roper, Nitin, Gao, Shaojian, Maity, Tapan K., Banday, A. Rouf, Zhang, Xu, Venugopalan, Abhilash, Cultraro, Constance M., Patidar, Rajesh, Sindiri, Sivasish, Brown, Anna-Leigh, Goncearenco, Alexander, Panchenko, Anna R., Biswas, Romi, Thomas, Anish, Rajan, Arun, Carter, Corey A., Kleiner, David E., Hewitt, Stephen M., Khan, Javed, Prokunina-Olsson, Ludmila, Guha, Udayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461561/
https://www.ncbi.nlm.nih.gov/pubmed/30840888
http://dx.doi.org/10.1016/j.celrep.2019.02.028

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