The Enhanced Tumor Specificity of TG6002, an Armed Oncolytic Vaccinia Virus Deleted in Two Genes Involved in Nucleotide Metabolism

Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved. We previously constructed a first-generation oncolytic vaccinia virus by expressing the suicide gene FCU1 inserted in the J2R locus that encode...

Descripción completa

Detalles Bibliográficos
Autores principales: Foloppe, Johann, Kempf, Juliette, Futin, Nicolas, Kintz, Jacqueline, Cordier, Pascale, Pichon, Christelle, Findeli, Annie, Vorburger, Fabien, Quemeneur, Eric, Erbs, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461584/
https://www.ncbi.nlm.nih.gov/pubmed/31011628
http://dx.doi.org/10.1016/j.omto.2019.03.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461584/
https://www.ncbi.nlm.nih.gov/pubmed/31011628
http://dx.doi.org/10.1016/j.omto.2019.03.005

Ejemplares similares