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Development of a Synthetic 3-ketosteroid Δ(1)-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells

Cholesterol is an essential component of membranes, which is acquired by cells via receptor-mediated endocytosis of lipoproteins or via de novo synthesis. In specialized cells, anabolic enzymes metabolize cholesterol, generating steroid hormones or bile acids. However, surplus cholesterol cannot be...

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Detalles Bibliográficos
Autores principales:	D’Arcy, Brandon M., Swingle, Mark R., Schambeau, Lindsay, Pannell, Lewis, Prakash, Aishwarya, Honkanen, Richard E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461610/ https://www.ncbi.nlm.nih.gov/pubmed/30979909 http://dx.doi.org/10.1038/s41598-019-42046-8

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