MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation

Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key transcriptional co-activator of many actin cytoskeletal genes, regulates genomic accessibility an...

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Detalles Bibliográficos
Autores principales: Hu, Xiao, Liu, Zongzhi Z., Chen, Xinyue, Schulz, Vincent P., Kumar, Abhishek, Hartman, Amaleah A., Weinstein, Jason, Johnston, Jessica F., Rodriguez, Elisa C., Eastman, Anna E., Cheng, Jijun, Min, Liz, Zhong, Mei, Carroll, Christopher, Gallagher, Patrick G., Lu, Jun, Schwartz, Martin, King, Megan C., Krause, Diane S., Guo, Shangqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461646/
https://www.ncbi.nlm.nih.gov/pubmed/30979898
http://dx.doi.org/10.1038/s41467-019-09636-6

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