A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, inactivating mutations in just one allele are responsible for a distinct yet rare...

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Detalles Bibliográficos
Autores principales: Roewenstrunk, Julia, Di Vona, Chiara, Chen, Jie, Borras, Eva, Dong, Chao, Arató, Krisztina, Sabidó, Eduard, Huen, Michael S. Y., de la Luna, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461666/
https://www.ncbi.nlm.nih.gov/pubmed/30979931
http://dx.doi.org/10.1038/s41598-019-42445-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461666/
https://www.ncbi.nlm.nih.gov/pubmed/30979931
http://dx.doi.org/10.1038/s41598-019-42445-x

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