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A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response
Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, inactivating mutations in just one allele are responsible for a distinct yet rare...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461666/ https://www.ncbi.nlm.nih.gov/pubmed/30979931 http://dx.doi.org/10.1038/s41598-019-42445-x |