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Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid

α-Synuclein aggregates, a key hallmark of the pathogenesis of Parkinson’s disease, can be amplified by using their seeding activity, and the evaluation of the seeding activity of cerebrospinal fluid (CSF) is reportedly useful for diagnosis. However, conventional shaking-based assays are time-consumi...

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Detalles Bibliográficos
Autores principales:	Kakuda, Keita, Ikenaka, Kensuke, Araki, Katsuya, So, Masatomo, Aguirre, César, Kajiyama, Yuta, Konaka, Kuni, Noi, Kentaro, Baba, Kousuke, Tsuda, Hiroshi, Nagano, Seiichi, Ohmichi, Takuma, Nagai, Yoshitaka, Tokuda, Takahiko, El-Agnaf , Omar M. A., Ogi, Hirotsugu, Goto, Yuji, Mochizuki, Hideki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461702/ https://www.ncbi.nlm.nih.gov/pubmed/30979935 http://dx.doi.org/10.1038/s41598-019-42399-0

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