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Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Whether fragile X mental retardation protein (FMRP) target mRNAs and neuronal activity contributing to elevated basal neuronal protein synthesis in fragile X syndrome (FXS) is unclear. Our proteomic experiments reveal that the de novo translational profile in FXS model mice is altered at steady stat...

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Detalles Bibliográficos
Autores principales:	Bowling, Heather, Bhattacharya, Aditi, Zhang, Guoan, Alam, Danyal, Lebowitz, Joseph Z., Bohm-Levine, Nathaniel, Lin, Derek, Singha, Priyangvada, Mamcarz, Maggie, Puckett, Rosemary, Zhou, Lili, Aryal, Sameer, Sharp, Kevin, Kirshenbaum, Kent, Berry-Kravis, Elizabeth, Neubert, Thomas A., Klann, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461708/ https://www.ncbi.nlm.nih.gov/pubmed/30979884 http://dx.doi.org/10.1038/s41467-019-09553-8

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