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Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study

BACKGROUND: Radiation-related caries (RRC) is one of the most significant oral toxicities of head and neck radiotherapy (HNRT); however, the potential of radiation to directly cause harmful dentin and pulpal effects and impair response to caries progression is controversial. MATERIAL AND METHODS: Th...

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Autores principales: Fonsêca, Jéssica-Montenegro, Palmier, Natália-Rangel, Silva, Wagner-Gomes, Faria, Karina-Morais, Vargas, Pablo-Agustin, Lopes, Marcio-Ajudarte, Salvajoli, João-Victor, Brandão, Thais-Bianca, Ribeiro, Ana-Carolina-Prado, Almeida, José-Flávio-Affonso, De Goes, Mario-Fernando, Santos-Silva, Alan-Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461726/
https://www.ncbi.nlm.nih.gov/pubmed/31001393
http://dx.doi.org/10.4317/jced.55370
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author Fonsêca, Jéssica-Montenegro
Palmier, Natália-Rangel
Silva, Wagner-Gomes
Faria, Karina-Morais
Vargas, Pablo-Agustin
Lopes, Marcio-Ajudarte
Salvajoli, João-Victor
Brandão, Thais-Bianca
Ribeiro, Ana-Carolina-Prado
Almeida, José-Flávio-Affonso
De Goes, Mario-Fernando
Santos-Silva, Alan-Roger
author_facet Fonsêca, Jéssica-Montenegro
Palmier, Natália-Rangel
Silva, Wagner-Gomes
Faria, Karina-Morais
Vargas, Pablo-Agustin
Lopes, Marcio-Ajudarte
Salvajoli, João-Victor
Brandão, Thais-Bianca
Ribeiro, Ana-Carolina-Prado
Almeida, José-Flávio-Affonso
De Goes, Mario-Fernando
Santos-Silva, Alan-Roger
author_sort Fonsêca, Jéssica-Montenegro
collection PubMed
description BACKGROUND: Radiation-related caries (RRC) is one of the most significant oral toxicities of head and neck radiotherapy (HNRT); however, the potential of radiation to directly cause harmful dentin and pulpal effects and impair response to caries progression is controversial. MATERIAL AND METHODS: Therefore, the aim of this study was to characterize the reactions of the dentin-pulp complex in teeth affected by RRC. Patients and methods: Twenty-two carious teeth extracted from 22 head and neck cancer (HNC) patients were divided into control (conventional caries; n=11) and irradiated (RRC; n=11) groups and paired matched by dental homology, clinical patterns of caries progression following the Post-Radiation Dental Index (PRDI) and microscopic depth of carious invasion. Histopathological characteristics based on morphological hierarchy, cell populations of dental pulp, blood vessels, neural elements, extracellular matrix components, inflammation, patterns of carious invasion and reactionary dentin presence were evaluated by optical light microscopy and histomorphometry. RESULTS: Mean PRDI scores were 3.2 for the control group and 3.8 for the irradiated group. Dentin demineralization patterns were also similar between the groups and the mean depths of demineralization were 1,158.58µm and 1,056.89µm for the control and irradiated groups, respectively. CONCLUSIONS: Pulp histopathological changes and dentin reaction patterns were similar between groups and varied according to the PRDI scores and carious lesions depth. Dentin and pulp reactions are highly preserved in RRC teeth. Key words:Cancer, radiotherapy, radiation-related caries, teeth, pulp.
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spelling pubmed-64617262019-04-18 Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study Fonsêca, Jéssica-Montenegro Palmier, Natália-Rangel Silva, Wagner-Gomes Faria, Karina-Morais Vargas, Pablo-Agustin Lopes, Marcio-Ajudarte Salvajoli, João-Victor Brandão, Thais-Bianca Ribeiro, Ana-Carolina-Prado Almeida, José-Flávio-Affonso De Goes, Mario-Fernando Santos-Silva, Alan-Roger J Clin Exp Dent Research BACKGROUND: Radiation-related caries (RRC) is one of the most significant oral toxicities of head and neck radiotherapy (HNRT); however, the potential of radiation to directly cause harmful dentin and pulpal effects and impair response to caries progression is controversial. MATERIAL AND METHODS: Therefore, the aim of this study was to characterize the reactions of the dentin-pulp complex in teeth affected by RRC. Patients and methods: Twenty-two carious teeth extracted from 22 head and neck cancer (HNC) patients were divided into control (conventional caries; n=11) and irradiated (RRC; n=11) groups and paired matched by dental homology, clinical patterns of caries progression following the Post-Radiation Dental Index (PRDI) and microscopic depth of carious invasion. Histopathological characteristics based on morphological hierarchy, cell populations of dental pulp, blood vessels, neural elements, extracellular matrix components, inflammation, patterns of carious invasion and reactionary dentin presence were evaluated by optical light microscopy and histomorphometry. RESULTS: Mean PRDI scores were 3.2 for the control group and 3.8 for the irradiated group. Dentin demineralization patterns were also similar between the groups and the mean depths of demineralization were 1,158.58µm and 1,056.89µm for the control and irradiated groups, respectively. CONCLUSIONS: Pulp histopathological changes and dentin reaction patterns were similar between groups and varied according to the PRDI scores and carious lesions depth. Dentin and pulp reactions are highly preserved in RRC teeth. Key words:Cancer, radiotherapy, radiation-related caries, teeth, pulp. Medicina Oral S.L. 2019-03-01 /pmc/articles/PMC6461726/ /pubmed/31001393 http://dx.doi.org/10.4317/jced.55370 Text en Copyright: © 2019 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Fonsêca, Jéssica-Montenegro
Palmier, Natália-Rangel
Silva, Wagner-Gomes
Faria, Karina-Morais
Vargas, Pablo-Agustin
Lopes, Marcio-Ajudarte
Salvajoli, João-Victor
Brandão, Thais-Bianca
Ribeiro, Ana-Carolina-Prado
Almeida, José-Flávio-Affonso
De Goes, Mario-Fernando
Santos-Silva, Alan-Roger
Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
title Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
title_full Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
title_fullStr Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
title_full_unstemmed Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
title_short Dentin-pulp complex reactions in conventional and radiation-related caries: A comparative study
title_sort dentin-pulp complex reactions in conventional and radiation-related caries: a comparative study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461726/
https://www.ncbi.nlm.nih.gov/pubmed/31001393
http://dx.doi.org/10.4317/jced.55370
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