Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed as chemopreventive agents for many tumours; however, the mechanism responsible for their anti-neoplastic activity remains elusive and the side effects due to cyclooxygenase (COX) inhibition prevent this clinical application...

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Detalles Bibliográficos
Autores principales: Dell’Omo, Giulia, Crescenti, Daniela, Vantaggiato, Cristina, Parravicini, Chiara, Borroni, Aurora Paola, Rizzi, Nicoletta, Garofalo, Mariangela, Pinto, Andrea, Recordati, Camilla, Scanziani, Eugenio, Bassi, Fabio Domenico, Pruneri, Giancarlo, Conti, Paola, Eberini, Ivano, Maggi, Adriana, Ciana, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461760/
https://www.ncbi.nlm.nih.gov/pubmed/30739913
http://dx.doi.org/10.1038/s41416-018-0372-7

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