Integrated analysis of multiple receptor tyrosine kinases identifies Axl as a therapeutic target and mediator of resistance to sorafenib in hepatocellular carcinoma

BACKGROUND: Aberrant activation of Axl is implicated in the progression of hepatocellular carcinoma (HCC). We explored the biologic significance and preclinical efficacy of Axl inhibition as a therapeutic strategy in sorafenib-naive and resistant HCC. METHODS: We evaluated Axl expression in sorafeni...

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Detalles Bibliográficos
Autores principales: Pinato, David J., Brown, Matthew W., Trousil, Sebastian, Aboagye, Eric O., Beaumont, Jamie, Zhang, Hua, Coley, Helen M., Mauri, Francesco A., Sharma, Rohini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461770/
https://www.ncbi.nlm.nih.gov/pubmed/30765873
http://dx.doi.org/10.1038/s41416-018-0373-6

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