Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry

The type III CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated genes) systems are bacterially encoded adaptive immune systems for defense against invading nucleic acids. They accomplish this task through the coordinated cleavage of invading substrates of single-...

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Detalles Bibliográficos
Autores principales: Guo, Minghui, Zhang, Kaiming, Zhu, Yuwei, Pintilie, Grigore D., Guan, Xiaoyu, Li, Shanshan, Schmid, Michael F., Ma, Zhuo, Chiu, Wah, Huang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461802/
https://www.ncbi.nlm.nih.gov/pubmed/30814678
http://dx.doi.org/10.1038/s41422-019-0151-x

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