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Lethal perinatal hypophosphatasia caused by a novel compound heterozygous mutation: a case report
BACKGROUND: Hypophosphatasia (HPP) is a rare hereditary disorder characterized by defective bone and tooth mineralization and deficiency of tissue non-specific alkaline phosphatase (TNAP) activity. The clinical presentation of HPP is highly variable, and the prognosis for the infantile form is poor....
Autores principales: | Yu, Fengdan, Wang, Junyi, Xu, Xiaojing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461808/ https://www.ncbi.nlm.nih.gov/pubmed/30979366 http://dx.doi.org/10.1186/s12887-019-1478-7 |
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