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Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl(Esr1)) play a causal role in the control of social behaviors, including aggression. Here we use six different viral-genetic tracing methods to systematically map the connectional arch...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462064/ https://www.ncbi.nlm.nih.gov/pubmed/30898882 http://dx.doi.org/10.1073/pnas.1817503116 |
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author | Lo, Liching Yao, Shenqin Kim, Dong-Wook Cetin, Ali Harris, Julie Zeng, Hongkui Anderson, David J. Weissbourd, Brandon |
author_facet | Lo, Liching Yao, Shenqin Kim, Dong-Wook Cetin, Ali Harris, Julie Zeng, Hongkui Anderson, David J. Weissbourd, Brandon |
author_sort | Lo, Liching |
collection | PubMed |
description | Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl(Esr1)) play a causal role in the control of social behaviors, including aggression. Here we use six different viral-genetic tracing methods to systematically map the connectional architecture of VMHvl(Esr1) neurons. These data reveal a high level of input convergence and output divergence (“fan-in/fan-out”) from and to over 30 distinct brain regions, with a high degree (∼90%) of bidirectionality, including both direct as well as indirect feedback. Unbiased collateralization mapping experiments indicate that VMHvl(Esr1) neurons project to multiple targets. However, we identify two anatomically distinct subpopulations with anterior vs. posterior biases in their collateralization targets. Nevertheless, these two subpopulations receive indistinguishable inputs. These studies suggest an overall system architecture in which an anatomically feed-forward sensory-to-motor processing stream is integrated with a dense, highly recurrent central processing circuit. This architecture differs from the “brain-inspired,” hierarchical feed-forward circuits used in certain types of artificial intelligence networks. |
format | Online Article Text |
id | pubmed-6462064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-64620642019-04-16 Connectional architecture of a mouse hypothalamic circuit node controlling social behavior Lo, Liching Yao, Shenqin Kim, Dong-Wook Cetin, Ali Harris, Julie Zeng, Hongkui Anderson, David J. Weissbourd, Brandon Proc Natl Acad Sci U S A PNAS Plus Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl(Esr1)) play a causal role in the control of social behaviors, including aggression. Here we use six different viral-genetic tracing methods to systematically map the connectional architecture of VMHvl(Esr1) neurons. These data reveal a high level of input convergence and output divergence (“fan-in/fan-out”) from and to over 30 distinct brain regions, with a high degree (∼90%) of bidirectionality, including both direct as well as indirect feedback. Unbiased collateralization mapping experiments indicate that VMHvl(Esr1) neurons project to multiple targets. However, we identify two anatomically distinct subpopulations with anterior vs. posterior biases in their collateralization targets. Nevertheless, these two subpopulations receive indistinguishable inputs. These studies suggest an overall system architecture in which an anatomically feed-forward sensory-to-motor processing stream is integrated with a dense, highly recurrent central processing circuit. This architecture differs from the “brain-inspired,” hierarchical feed-forward circuits used in certain types of artificial intelligence networks. National Academy of Sciences 2019-04-09 2019-03-21 /pmc/articles/PMC6462064/ /pubmed/30898882 http://dx.doi.org/10.1073/pnas.1817503116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | PNAS Plus Lo, Liching Yao, Shenqin Kim, Dong-Wook Cetin, Ali Harris, Julie Zeng, Hongkui Anderson, David J. Weissbourd, Brandon Connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
title | Connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
title_full | Connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
title_fullStr | Connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
title_full_unstemmed | Connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
title_short | Connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
title_sort | connectional architecture of a mouse hypothalamic circuit node controlling social behavior |
topic | PNAS Plus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462064/ https://www.ncbi.nlm.nih.gov/pubmed/30898882 http://dx.doi.org/10.1073/pnas.1817503116 |
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