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Connectional architecture of a mouse hypothalamic circuit node controlling social behavior

Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl(Esr1)) play a causal role in the control of social behaviors, including aggression. Here we use six different viral-genetic tracing methods to systematically map the connectional arch...

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Detalles Bibliográficos
Autores principales: Lo, Liching, Yao, Shenqin, Kim, Dong-Wook, Cetin, Ali, Harris, Julie, Zeng, Hongkui, Anderson, David J., Weissbourd, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462064/
https://www.ncbi.nlm.nih.gov/pubmed/30898882
http://dx.doi.org/10.1073/pnas.1817503116
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author Lo, Liching
Yao, Shenqin
Kim, Dong-Wook
Cetin, Ali
Harris, Julie
Zeng, Hongkui
Anderson, David J.
Weissbourd, Brandon
author_facet Lo, Liching
Yao, Shenqin
Kim, Dong-Wook
Cetin, Ali
Harris, Julie
Zeng, Hongkui
Anderson, David J.
Weissbourd, Brandon
author_sort Lo, Liching
collection PubMed
description Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl(Esr1)) play a causal role in the control of social behaviors, including aggression. Here we use six different viral-genetic tracing methods to systematically map the connectional architecture of VMHvl(Esr1) neurons. These data reveal a high level of input convergence and output divergence (“fan-in/fan-out”) from and to over 30 distinct brain regions, with a high degree (∼90%) of bidirectionality, including both direct as well as indirect feedback. Unbiased collateralization mapping experiments indicate that VMHvl(Esr1) neurons project to multiple targets. However, we identify two anatomically distinct subpopulations with anterior vs. posterior biases in their collateralization targets. Nevertheless, these two subpopulations receive indistinguishable inputs. These studies suggest an overall system architecture in which an anatomically feed-forward sensory-to-motor processing stream is integrated with a dense, highly recurrent central processing circuit. This architecture differs from the “brain-inspired,” hierarchical feed-forward circuits used in certain types of artificial intelligence networks.
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spelling pubmed-64620642019-04-16 Connectional architecture of a mouse hypothalamic circuit node controlling social behavior Lo, Liching Yao, Shenqin Kim, Dong-Wook Cetin, Ali Harris, Julie Zeng, Hongkui Anderson, David J. Weissbourd, Brandon Proc Natl Acad Sci U S A PNAS Plus Type 1 estrogen receptor-expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl(Esr1)) play a causal role in the control of social behaviors, including aggression. Here we use six different viral-genetic tracing methods to systematically map the connectional architecture of VMHvl(Esr1) neurons. These data reveal a high level of input convergence and output divergence (“fan-in/fan-out”) from and to over 30 distinct brain regions, with a high degree (∼90%) of bidirectionality, including both direct as well as indirect feedback. Unbiased collateralization mapping experiments indicate that VMHvl(Esr1) neurons project to multiple targets. However, we identify two anatomically distinct subpopulations with anterior vs. posterior biases in their collateralization targets. Nevertheless, these two subpopulations receive indistinguishable inputs. These studies suggest an overall system architecture in which an anatomically feed-forward sensory-to-motor processing stream is integrated with a dense, highly recurrent central processing circuit. This architecture differs from the “brain-inspired,” hierarchical feed-forward circuits used in certain types of artificial intelligence networks. National Academy of Sciences 2019-04-09 2019-03-21 /pmc/articles/PMC6462064/ /pubmed/30898882 http://dx.doi.org/10.1073/pnas.1817503116 Text en Copyright © 2019 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle PNAS Plus
Lo, Liching
Yao, Shenqin
Kim, Dong-Wook
Cetin, Ali
Harris, Julie
Zeng, Hongkui
Anderson, David J.
Weissbourd, Brandon
Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
title Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
title_full Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
title_fullStr Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
title_full_unstemmed Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
title_short Connectional architecture of a mouse hypothalamic circuit node controlling social behavior
title_sort connectional architecture of a mouse hypothalamic circuit node controlling social behavior
topic PNAS Plus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462064/
https://www.ncbi.nlm.nih.gov/pubmed/30898882
http://dx.doi.org/10.1073/pnas.1817503116
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