Cargando…

Risk variants disrupting enhancers of T(H)1 and T(REG) cells in type 1 diabetes

Genome-wide association studies (GWASs) have revealed 59 genomic loci associated with type 1 diabetes (T1D). Functional interpretation of the SNPs located in the noncoding region of these loci remains challenging. We perform epigenomic profiling of two enhancer marks, H3K4me1 and H3K27ac, using prim...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Peng, Uzun, Yasin, He, Bing, Salamati, Sarah E., Coffey, Julie K. M., Tsalikian, Eva, Tan, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462079/
https://www.ncbi.nlm.nih.gov/pubmed/30910956
http://dx.doi.org/10.1073/pnas.1815336116